Dendritic and synaptic protection: is it enough to save the retinal ganglion cell body and axon?

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Title Journal of Neuro-Ophthalmology, June 2008, Volume 28, Issue 2
Date 2008-06
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6m93fq4
Setname ehsl_novel_jno
ID 225715
Reference URL https://collections.lib.utah.edu/ark:/87278/s6m93fq4

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Title Dendritic and synaptic protection: is it enough to save the retinal ganglion cell body and axon?
Creator Morquette, Junie Barbara; Di Polo, Adriana
Affiliation Department of Pathology and Cell Biology and Groupe de Recherche sur le Systme Nerveux Central, University of Montreal, Montreal, Quebec, Canada.
Abstract Glaucoma and other optic neuropathies have been traditionally viewed as diseases of the optic nerve that lead to retinal ganglion cell (RGC) degeneration. Accordingly, the primary aim of neuroprotective strategies has been to preserve RGC axons and soma. RGCs are complex and highly polarized central neurons, and their pathologic response in disease is likely to be an integration of signals from all cellular compartments-axons, soma, dendrites, and synaptic contacts. We focus on the role of dendrites and dendritic spines in normal neuronal function, neurologic disorders, and glaucoma. The need to understand the mechanisms underlying RGC dendrite and synapse degeneration in glaucoma and other optic neuropathies is compelling, as it may provide insight into novel therapeutic strategies to prevent vision loss.
Subject Animals; Axons; Axons; Cell Communication; Dendrites; Dendritic Spines; Humans; Nerve Degeneration; Optic Nerve Diseases; Presynaptic Terminals; Retinal Ganglion Cells; Synapses
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 225710
Reference URL https://collections.lib.utah.edu/ark:/87278/s6m93fq4/225710
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