| Identifier |
walsh_2013_s1_c2-2 |
| Title |
Ain't No Sunshine When You Are Gone! |
| Creator |
Veeral S. Shah; Linda Sternau; Michelle Felicella; Sanders Dubovy; Chris Alabiad; Norman J. Schatz; Byron L. Lam |
| Affiliation |
(VSS) (SD) (CA) (NJS) Bascom Palmer Eye Institute / University of Miami, Miami, FL; (LS) (MF) Memorial Regional Hospital/ Neurosurgery Division Hollywood, FL |
| Subject |
Adulthood Malignant Glioma; Optic Neuritis; Anaplastic astrocytoma; Temozolomide; Central Vein/Artery occlusion |
| History |
An 18 year-old Latin American female presented with progressive visual loss OD over 6 weeks. She initially had blurry vision and photophobia OD with a central scotoma OD on HVF testing. At that time, examination revealed a right swollen optic nerve with retinal hemorrhages. She was otherwise healthy, and denied any eye pain, neurological deficits, trauma medications, tobacco, alcohol, or drug use. |
| Pathology |
Intracanalicular right optic nerve specimen showed dense fibrovascular tissue with macrophage infiltrates. Intracranial portion of the right optic nerve specimen revealed large pleomorphic and hyperchromatic atypical cells infiltrating the nerve. Sectioned tissue underwent immunostaining for GFAP, Ki67, Olig 2, and IDH1. These atypical cells were strongly GFAP positive, but were negative for Olig and IDH1. The Ki67 index of the posterior margin of the tissue was 4-5%. |
| Disease/Diagnosis |
Malignant Glioma optic nerve pathway (a pediatric case of Malignant Glioma of Adulthood) |
| Clinical |
A fat suppressed orbital MRI scan showed evidence of optic nerve enhancement OD. |
| Presenting Symptom |
An 18 year-old Latin American female presented with progressive visual loss OD over 6 weeks. |
| Neuroimaging |
MRI |
| Treatment |
This patient was managed aggressively with surgical resection of the pre-chiasmal tumor, and treated post-operatively with Temozolomide and stereotactic radiotherapy treatment. |
| Date |
2013-02 |
| References |
1. Hoyt WF, Meshel LG, Lessell S, Schatz NJ, Suckling RD. Malignant optic glioma of adulthood. Brain, 96(1), 121-32, 1973. 2. Millar WS, Tartaglino LM, Sergott RC, et al: MR of malignant optic glioma of adulthood. Am J Neuroradiol, 16, 1673-1676, 1995. 3. Miller, N.R. Primary tumours of the optic nerve and its sheath. Eye (Lond), 18, 1026-1037, 2004. 4. Spoor TC, Kennerdell JS, Martinez AJ, Zorub D. Malignant gliomas of the optic nerve pathways, Am J Ophthalmol, Feb;89(2), 284-92, 1980. |
| Language |
eng |
| Format |
video/mp4 |
| Type |
Image/MovingImage |
| Source |
45th Annual Frank Walsh Society Meeting |
| Relation is Part of |
NANOS Annual Meeting Frank B. Walsh Sessions; 2013 |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Walsh Session Annual Meeting Archives: https://novel.utah.edu/Walsh/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6jh6hr0 |
| Setname |
ehsl_novel_fbw |
| ID |
179232 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6jh6hr0 |
