| Identifier |
walsh_1982_s3_c1 |
| Title |
In Vivo Antibody Mediated Optic Nerve Demyelination |
| Creator |
Robert C. Sergott, MD |
| Subject |
Demyelinating Autoimmune Diseases, CNS; Optic Neuritis; Multiple Sclerosis; Antibodies |
| History |
Demyelination of the central nervous system (CNS) without coincident axonal damage is a characteristic pathologic lesion in multiple sclerosis (MS) and in optic neuritis, one of the frequent findings in MS. |
| Pathology |
Demyelinating lesions of the CNS |
| Disease/Diagnosis |
Multiple Sclerosis |
| Clinical |
Sera and concentrated cerebrospinal fluid (CSF) from patients with acute exacerbations of MS have produced in vitro demyelination of rodent CNS tissue cultures. |
| Presenting Symptom |
Demyelination of the central nervous system |
| Neuroimaging |
N/A |
| Treatment |
N/A |
| Date |
2007-12-04 |
| References |
1. Prinaas J: Pathology of the early lesions in multiple sclerosis Human Pathology 6:531-554, 1975. 2. Prineas JW, Raine CS: Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions. Neurology 26:29-32, 1976. 3. Norton WT: Isolation and characterization of myelin. "Myelin". Edited by P. Morell. New York, Plenum Press, 1977, pp. 161-199. 4. Saida T, Silberberg DH, Fry JM, et.al: Demyelinating anti-galacto-cerebroside antibodies in EAN and EAE. J Neuropathol Exp Neurol 36:627, 1977. 5. Fry JM, Weissbarth S, Lehrer GM, et.al: Cerebroside antibody inhibits sulfatide synthesis and myelination and demyelinates in cord tissue cultures Sflifinaa 183:540-542, 197U. 6. Saida K, Saida T, Brown MJ, Silberberg DH: In vivo demyelination induced by intraneural- injection of anti-galactooereboside serium. Am J Pathol. 95:99-116, 1979. 7. Llsak RP, Saida T, Kennedy PGE, et.al: EAE, EAN and galactocerebroside sera bind to oligodendrocytes and Schwann cells. J Neurol Sci 48:287-296, 1980. |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
14th Annual Frank Walsh Society Meeting |
| Relation is Part of |
Session 3, Case 1, Walsh Session, NANOS 1982 |
| Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
| Rights Management |
Copyright 2008. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6v69nb3 |
| Contributor Primary |
Sergott, Robert C. |
| Contributor Secondary |
Brown, Mark J. Silberberg, Donald H. |
| Setname |
ehsl_novel_fbw |
| ID |
178145 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6v69nb3 |
