Title |
The effect of cyclophosphamide on B cells in spleen (rat) |
Creator |
Poels, Lambert G. |
Contributor |
Lambert G. Poels, PhD, UMC St Radboud Nijmegen; Paul H. K. Jap, PhD, UMC St Radboud Nijmegen |
Date |
2010-06-11 |
Subject |
cyclophosphamide; immunosuppression; immunofluorescence; B lymphocytes |
Description |
Stain: Immunofluorescence of Vector red using Mark-1 antibody against B cells. A: Normal rat spleen. (1) the dark, unstained area represents the PALS (periarteriolar lymphatic sheath) filled with T cells. (2) red-stained germinal centre of a B cell follicle that is surrounded by the marginal zone (3). Note that B cells are also distributed in the red pulp area (4). B: 4 days after a single treatment with cyclophosphamide the number of red-stained B cells are considerably reduced in the follicles (2) and marginal zones (3), but also in the red pulp (4). The cyclophosphamide treatment causes a temporarily severe reduction of the immune response to antigens, partly to the reduced levels of B cells. |
Subtype |
Image |
Format |
image/jpeg |
Rights |
https://rightsstatements.org/page/CNE/1.0/ |
Collection |
Poja Histology Collection - Lymphatic Tissues and Organs Subset |
ARK |
ark:/87278/s65f1v42 |
Setname |
ehsl_heal |
ID |
890920 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s65f1v42 |