Publication Type |
thesis |
School or College |
School of Medicine |
Department |
Pathology |
Author |
Wilcock, Diane Marie |
Title |
Improving peanut allergy diagnosis using specific immunoglobulin E peanut component and basophil activation testing |
Date |
2016-08 |
Description |
Peanut allergy is one of the most prevalent and deadliest food allergies. As public awareness has increased about the dangers of food allergies, there has been a corresponding increase in the research on peanut allergies. Significant increases in practical applications of our knowledge have occurred in the last few decades including questions that have been answered as to the best routes and methods of exposure to peanuts, there are innovative new therapies for possibly resolving peanut allergies, and cell based assays can now utilize components of peanuts that have significantly better predictive power and reproducibility than the previous whole peanut extracts. The next step is to be able to correlate laboratory tests to the severity of peanut allergy symptoms without having to expose the patients to the suspected food and risk urticaria, anaphylaxis, or even death. Basophil Activation Testing (BAT) is a promising way to do this and to help improve the correct diagnosis of potentially severe, life-threatening peanut allergy. The results from this study showed that BAT tests were able to correctly predict the outcome of food challenges as well as discriminate between peanut-sensitized and peanut allergic patients. |
Type |
Text |
Publisher |
University of Utah |
Subject MESH |
Peanut Hypersensitivity; Anaphylaxis; Basophils; Immunoglobulin E; Enzyme-Linked Immunosorbent Assay; Radioallergosorbent Test; Basophil Degranulation Test; Hypersensitivity, Immediate; Skin Tests; Predictive Value of Tests; Sensitivity and Specificity; Sublingual Immunotherapy; Time Factors; Desensitization, Immunologic; Food Contamination; Food Safety; Food Labeling |
Dissertation Institution |
University of Utah |
Dissertation Name |
Master of Science |
Language |
eng |
Relation is Version of |
Digital reproduction of Improving Peanut Allergy Diagnosis Using Specific Immunoglobulin E Peanut Component and Basophil Activation Testing |
Rights Management |
Copyright © Diane Marie Wilcock 2016 |
Format Medium |
application/pdf |
Format Extent |
1,018,966 bytes |
Source |
Original in Marriott Library Special Collections |
ARK |
ark:/87278/s69p7gfg |
Setname |
ir_etd |
ID |
1423173 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s69p7gfg |