Genetic epidemiologic methods for common, complex diseases: application to cardiovascular disease

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Title Genetic epidemiologic methods for common, complex diseases: application to cardiovascular disease
Publication Type dissertation
School or College School of Medicine
Department Biomedical Informatics
Author Horne, Benjamin Davies
Date 2005-08
Description Historically, genes harboring causative mutations for rare Mendelian diseases have been relatively easy to identify. Recent attempts to discover the genetic causes of complex diseases that are relatively common in human populations have, however, not been as successful. The difficulties encountered in the genetic study of common diseases include problems with study design, study population, definition of phenotype, and statistical approach. Genetic studies of cardiovascular disease phenotypes provide a prime example of these problems. Specifically, coronary heart disease is a prevalent disease with multiple risk factors including many potential environmental and inherited contributors. Unfortunately, the deciphering of the genetic component for coronary disease has experienced many promising findings that have not been corroborated. The aims of this dissertation project were to evaluate genetic contributions to cardiovascular diseases, and coronary heart disease in particular, using large populations with well-defined phenotypes and well-characterized genetic factors, and to explore improved methods of genetic analysis that account for the complexity of genetics and environment. These aims were accomplished through application to the three primary areas of genetic epidemiology: population genetic analysis, linkage analysis of phenotypes to genetic loci, and candidate genes association analysis.
Type Text
Publisher University of Utah
Subject Genetics; Cardiovascular System
Subject MESH Coronary Disease; Cardiovascular Diseases
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "Genetic epidemiologic methods for common, complex diseases: application to cardiovascular disease." Spencer S. Eccles Health Sciences Library. Print version of "Genetic epidemiologic methods for common, complex diseases: application to cardiovascular disease." available at J. Willard Marriott Library Special Collection. RC39.5 2005 .H67.
Rights Management © Benjamin Davies Horne.
Format application/pdf
Format Medium application/pdf
Format Extent 3,314,724 bytes
Identifier undthes,5386
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Funding/Fellowship NIH grant HL073117, NIH gran GM31575, Deseret Foundation, and Intermountain Health Care (IHC)
Master File Extent 3,314,766 bytes
ARK ark:/87278/s6571drp
Setname ir_etd
ID 190535
Reference URL https://collections.lib.utah.edu/ark:/87278/s6571drp
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