Anti-zona pellucida antibodies in the serum and the follicular fluid of infertility patients undergoing in vitro fertilization

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Title Anti-zona pellucida antibodies in the serum and the follicular fluid of infertility patients undergoing in vitro fertilization
Publication Type thesis
School or College School of Medicine
Department Biomedical Informatics
Author Roth, Stephanie Louise
Date 1984-12
Description Using an indirect immunofluorescence assay with porcine ova, 11 of 69 (15.9%) women with infertility and 13 of 46 (28.3%) women with recurrent spontaneous abortion of undetermined etiology had anti-zona pellucida antibody titers of 1.4 or greater. In contrast, none of 56 control individuals has positive anti-zona pellucida titers. Forty-two infertility patients undergoing in vitro fertilization were fertilized for levels of circulating anti-zona pellucida antibodies. Six of 42 patients (14.3%) had circulating antibody titers of 1:4 or greater. In 16 of these patients, paired serum and follicular fluid antibody titers were compared. Of these, five had positive serum titers (1:4 or greater). Of these five, four were found to also have antibody in the follicular fluid at a titer of 1:2 or greater. Of the remaining 11 samples that were negative for serum antibody, 5 of the corresponding follicular fluids were also negative and 6 were positive at undiluted only. These results demonstrate that antibodies against the zona pellucia can pass from the serum into the follicular fluid, and suggest that there is a relationship between the presence of serum and intrafollicular autoantibodies against the zona pellucia. The success of in vitro fertilization was correlated to the presence of anti-zona pellucida antibodies. Serum titers of 1:4 or greater, which have been suggested to be associated with infertility, did not prevent successful fertilization in vitro. However, the patient with an anti-zona pellucida titer of 1:16 was also the only patient whose ovum was unfertilized by husband's or unrelated donor sperm. In conclusion, antibodies to zona pellucia are found in the serum of some infertile women and with histories of recurrent abortion. Also, antibodies against the zona pellucia are present in the follicular fluid at concentrations similar to those found in the serum. Finally, specific antibody titers may have an effect on the outcome of in vitro fertilization.
Type Text
Publisher University of Utah
Subject Human; Anti-antibodies; Immunology
Subject MESH Infertility, Female; Fertilization in Vitro
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "Anti-zona pellucida antibodies in the serum and the follicular fluid of infertility patients undergoing in vitro fertilization." Spencer S. Eccles Health Sciences Library. Print version of "Anti-zona pellucida antibodies in the serum and the follicular fluid of infertility patients undergoing in vitro fertilization." available at J. Willard Marriott Library Special Collection. RG41.5 1984 .R68.
Rights Management © Stephanie Louise Roth.
Format application/pdf
Format Medium application/pdf
Format Extent 596,143 bytes
Identifier undthes,4643
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Master File Extent 596,187 bytes
ARK ark:/87278/s6gq70n8
Setname ir_etd
ID 191888
Reference URL https://collections.lib.utah.edu/ark:/87278/s6gq70n8
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