Should I Have Teprotumumab or Surgery?

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Identifier 20230315_nanos_surgery1_06
Title Should I Have Teprotumumab or Surgery?
Creator Alison V. Crum, MD
Affiliation John A. Moran Eye Center, University of Utah, Salt Lake City, UT
Subject Thyroid Orbitopathy; Thyroid Eye Disease; Teprotumumab; Proptosis; Diplopia
Description Pathophysiology of thyroid eye disease/thyroid orbitopathy and teprotumumab: In orbitopathy, it is believed that there is a cross reaction of thyroid auto-antibodies with the thyrotropin receptor (TSHR) and the insulin growth factor receptor (IGFR) on orbital fibroblasts.
Date 2023-03
References 1. Khong JJ et al. Medical treatment in thyroid eye disease in 2020. Br J Ophthalmol. 2021; 105: 299-305. doi: 10/1136/bjophthalmol-2020-316051. 2. Douglas, R. S. et al. Teprotumumab for the Treatment of Active Thyroid Eye Disease. New England Journal of Medicine 2020; 382:341-352. doi: 10.1056/NEJMoa1910434. 3. Douglas, R. S. et al. Teprotumumab Efficacy, Safety, and Durability in Longer-Duration Thyroid Eye Disease and Re-Treatment. Ophthalmology April 2022; 129(4): 438-449. doi: 10.1016/j.ophtha.2021.10.017. 4. Haymart, Megan R. Year in Thyroidology-Recent Developments and Future Challenges: Clinical Science Review. Thyroid 2022 32(1):9-13. doi: 10.1089/thy.2021.0562. 5. Bhatti and Dutton. Thyroid Eye Disease: Therapy in the Active Phase. J Neuro-ophthalmol 2014; 34:186-197. doi: 10.1097/wno.0000000000000128.
Language eng
Format video/mp4
Type Image/MovingImage
Source 2023 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS Annual Meeting 2023: Ophthalmic Surgery in the Neuro-Ophthalmic Patient: https://novel.utah.edu/collection/NAM/toc/
Collection Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6reseyz
Setname ehsl_novel_nam
ID 2386013
Reference URL https://collections.lib.utah.edu/ark:/87278/s6reseyz
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