Ain't No Sunshine When You Are Gone!

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Identifier walsh_2013_s1_c2-2
Title Ain't No Sunshine When You Are Gone!
Creator Veeral S. Shah; Linda Sternau; Michelle Felicella; Sanders Dubovy; Chris Alabiad; Norman J. Schatz; Byron L. Lam
Affiliation (VSS) (SD) (CA) (NJS) Bascom Palmer Eye Institute / University of Miami, Miami, FL; (LS) (MF) Memorial Regional Hospital/ Neurosurgery Division Hollywood, FL
Subject Adulthood Malignant Glioma; Optic Neuritis; Anaplastic astrocytoma; Temozolomide; Central Vein/Artery occlusion
History An 18 year-old Latin American female presented with progressive visual loss OD over 6 weeks. She initially had blurry vision and photophobia OD with a central scotoma OD on HVF testing. At that time, examination revealed a right swollen optic nerve with retinal hemorrhages. She was otherwise healthy, and denied any eye pain, neurological deficits, trauma medications, tobacco, alcohol, or drug use.
Pathology Intracanalicular right optic nerve specimen showed dense fibrovascular tissue with macrophage infiltrates. Intracranial portion of the right optic nerve specimen revealed large pleomorphic and hyperchromatic atypical cells infiltrating the nerve. Sectioned tissue underwent immunostaining for GFAP, Ki67, Olig 2, and IDH1. These atypical cells were strongly GFAP positive, but were negative for Olig and IDH1. The Ki67 index of the posterior margin of the tissue was 4-5%.
Disease/Diagnosis Malignant Glioma optic nerve pathway (a pediatric case of Malignant Glioma of Adulthood)
Clinical A fat suppressed orbital MRI scan showed evidence of optic nerve enhancement OD.
Presenting Symptom An 18 year-old Latin American female presented with progressive visual loss OD over 6 weeks.
Neuroimaging MRI
Treatment This patient was managed aggressively with surgical resection of the pre-chiasmal tumor, and treated post-operatively with Temozolomide and stereotactic radiotherapy treatment.
Date 2013-02
References 1. Hoyt WF, Meshel LG, Lessell S, Schatz NJ, Suckling RD. Malignant optic glioma of adulthood. Brain, 96(1), 121-32, 1973. 2. Millar WS, Tartaglino LM, Sergott RC, et al: MR of malignant optic glioma of adulthood. Am J Neuroradiol, 16, 1673-1676, 1995. 3. Miller, N.R. Primary tumours of the optic nerve and its sheath. Eye (Lond), 18, 1026-1037, 2004. 4. Spoor TC, Kennerdell JS, Martinez AJ, Zorub D. Malignant gliomas of the optic nerve pathways, Am J Ophthalmol, Feb;89(2), 284-92, 1980.
Language eng
Format video/mp4
Type Image/MovingImage
Source 45th Annual Frank Walsh Society Meeting
Relation is Part of NANOS Annual Meeting Frank B. Walsh Sessions; 2013
Collection Neuro-Ophthalmology Virtual Education Library: Walsh Session Annual Meeting Archives: https://novel.utah.edu/Walsh/
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6jh6hr0
Setname ehsl_novel_fbw
ID 179232
Reference URL https://collections.lib.utah.edu/ark:/87278/s6jh6hr0
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