Papilledema in a Patient Being Treated for Multiple Sclerosis

A27-year-old woman is diagnosed with and treated for multiple sclerosis when she presents with ataxia, vomiting, dysphagia, slurred speech, left sided weakness, and diplopia. A few years later, she develops papilledema. This led to neuro-ophthalmic consultation, which uncovered markedly elevated spinal fluid protein and diffusely enlarged eye muscles.

UPFRONT Case Section Editor: Larry Frohman, MD Papilledema in a Patient Being Treated for Multiple Sclerosis Larry Frohman, MD, Roger E. Turbin, MD, Peter J. Wawrzusin, MD, Gaurav Srivastava, MD, Nicole M. Sakla, DO A 27-year-old woman is diagnosed with and treated for multiple sclerosis when she presents with ataxia, vomiting, dysphagia, slurred speech, left sided weakness, and diplopia. A few years later, she develops papilledema. This led to neuro-ophthalmic consultation, which uncovered markedly elevated spinal fluid protein and diffusely enlarged eye muscles. These features led to a new neurologic diagnosis and an underlying systemic disease being uncovered, with new treatment regimens applied. The case is available to download through the following link: https://journals.lww.com/jneuro-ophthalmology/Documents/ JNO%20Upfront%20Cases/UPFRONT%20Case%205%20%20Papilledema%20in%20a%20Patient%20Being% 20Treated%20for%20Multiple%20Sclerosis.pptx. Departments of Ophthalmology (LF, RT, PW, GS) and Neurosciences (LF), Rutgers-New Jersey Medical School, Newark, NJ; and Department of Radiology (NS), Newark-Beth Israel Medical Center, Newark, NJ. The authors report no conflicts of interest. Address correspondence to Larry Frohman, MD, 90 Bergen Street, Newark, NJ 07103; E-mail: [e-mail] e816 Frohman et al: J Neuro-Ophthalmol 2021; 41: e816 Copyright © North American Neuro-Ophthalmology Society. Unauthorized reproduction of this article is prohibited.