Is Normal Tension Glaucoma Related to Altered CSF-Dynamics and Composition?

Cerebrospinal fluid (CSF) is thought to be homogeneous in composicion and to be distributed evenly with a continuous flow through all CSF spaces including the subarachoid space (SAS) of the optic nerve (ON). This concept has been challenged based on the measurement of a marked concentration gradient of the brain-derived protein betatrace (L-PGDS) between the spinal CSF and the CSF in the SAS surrounding the ON in patients with idiopathic imracranial hypertension (IIH), optic nerve sheath meningioma and non-artericic anterior ischemic optic neuropathy and normal tension glaucoma.