Outcomes Evaluation for Adult Ewing's Sarcoma, Osteosarcoma, and Rhabdomyosarcoma Patients Treated with Off-label Children's Oncology Group Protocols

Sarcoma is a rare malignancy in adults compared to children, with sarcoma accounting for 1% of malignancies in adults compared to 15% of malignancies in children. Sarcoma treatment regimens consist of a multimodality approach consisting of surgery, radiation, and chemotherapy. Improvements in pediatric survival have been accomplished through the use of protocol regimens developed by the Children's Oncology Group (COG). Studies that focused on the adult sarcoma population have been small, retrospective studies that have reported poorer outcomes compared to the pediatric population. There is little information regarding outcomes in adults with osteosarcoma, rhabdomyosarcoma and Ewing's sarcoma in the adult patient population, and no information available specific to the Huntsman Cancer Institute. Conclusion: Amongst responders, COG protocols provide potential for durable response. Common toxicities include myelosuppression and nausea/vomiting. Further research required in adult sarcoma regimens.