| Identifier |
20130211_nanos_sciplatform1_05 |
| Title |
TrkB Neurotrophin Receptor Activation with Pharmacophore as Possible Treatment for Anterior Ischemic Optic Neuropathy |
| Creator |
Y. Joyce Liao; M. A. Shariati; Gun H. Lee; Jeff Ma; Tao Yang; Chandrani Chakraborty; Ben A. Barres; Frank M. Longo |
| Affiliation |
(JL) (MAS) (GHL) (JM) (TY) (CC) (BAB) (FML) Stanford Department of Ophthalmology, Stanford, CA; Stanford Department of Neurology, Stanford, CA; Stanford Department of Neurobiology, Stanford, CA |
| Subject |
Anterior Ischemic Optic Neuropathy; Neurotrophin; TrkB; Retinal Ganglion Cells; Treatment |
| Description |
Anterior ischemic optic neuropathy (AION) is the most common acute optic neuropathy in older adults, and there is currently no effective treatment. Retrogradely transported neurotrophins like BDNF (brain-derived neurotrophic factor) and its high affinity receptor TrkB are particularly important in the survival of retinal ganglion cells (RGCs) following injury,1 leading to the hypothesis that restoration of neurotrophic support may be an effective therapeutic approach. In this study, we tested the effects of LM22A-4, a small molecule pharmacophore that specifically activates the TrkB receptor with nanomolar affinity,2 on RGC survival and as treatment of experimental AION. |
| Date |
2013-02-11 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2013 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS 2013: Platform Presentations (Session I) |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6vh8vj0 |
| Setname |
ehsl_novel_nam |
| ID |
183397 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6vh8vj0 |
