The diurnal variation of norepinephrine in the rat parotid gland

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Title The diurnal variation of norepinephrine in the rat parotid gland
Publication Type thesis
School or College College of Pharmacy
Department Pharmacology & Toxicology
Author Soderberg, Robert Carl
Date 1972-06
Description The parasympathetic and sympathetic nervous systems are both involved in the control of secretion of the major salivary glands although the parasympathetic system is more dominant. Previous work by Sreebny and Johnson (1969) has demonstrated a diurnal variation in three secretory enzymes of the rat parotid gland. The possibility that there may also be a diurnal variation of the sympathetic neural transmitter, norepinephrine, was investigated. It was also anticipated a diurnal variation of norepinephrine in the rate parotid might show some correlation with the eating cycle. After the 24 hour eating pattern of the rat was determined, the parotid glands were removed form separate groups of experimental animals and assayed for norepinephrine content and tyrosine hydroxylase activity. The results obtained indicate that the levels of norepinephrine in the rate parotid did exhibit a diurnal variation with higher levels occurring during periods of light and lower levels occurring during periods of darkness. The activiaty of tyrosine hydroxylase, which is the rate limiting enzyme in the synthesis of norepinephrine from tyrosine, correlated with levels of norepinephrine throughout the 24-hour period. It was concluded that norepinephrine in the rat parotid demonstrates a diurnal variation that appears to parallel the activiaty of tyrosine hydroxylase. Also, norepinephrine and tyrosine hydroxylase activity appear to parallel the diurnal variation of three secretory enzymes as shown by Sreebny. These findings suggest that the sympathetic nervous systems may have a more functional role in the secretory control of the rat parotid gland than was previously considered.
Type Text
Publisher University of Utah
Subject Laboratory Animals; Rats
Subject MESH Norepinephrine; Parotid Gland
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "The diurnal variation of norepinephrine in the rat parotid gland." Spencer S. Eccles Health Sciences Library. Print version of "The diurnal variation of norepinephrine in the rat parotid gland." available at J. Willard Marriott Library Special Collection. QP6.5 1972 .S6.
Rights Management © Robert C. Soderberg.
Format application/pdf
Format Medium application/pdf
Format Extent 317,595 bytes
Identifier undthes,5494
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Funding/Fellowship U.S. Public Health Service grant (5-TO1-DE00252-03).
Master File Extent 317,625 bytes
ARK ark:/87278/s6h9973x
Setname ir_etd
ID 191942
Reference URL https://collections.lib.utah.edu/ark:/87278/s6h9973x
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