The effect of phenytoin on the dispositon of disopyramide

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Title The effect of phenytoin on the dispositon of disopyramide
Publication Type dissertation
School or College College of Pharmacy
Department Pharmacotherapy
Author Rando, Janice
Date 1984-06
Description The combining of two drugs may cause an interaction which either enhances or diminished the beneficial or adverse effects of either agent. An interaction between two antiarrhythmic drugs, disopyramide and phenytoin has been reported. In this interaction, phenytoin appears to decrease the therapeutic effect while enhancing the toxic effects of disopyramide. Disopyramide slows the conductions velocity, prolongs the effective refractory period of the action potential and decreases automaticity of normal and diseased fibers in the heart. These properties enable disopyramide to treat both atrial and ventricular arrhythmias. Phenytoin, although not approved by the FDA as an antiarrhythmic drug, is often combined with other agents such as disopyramide in the treatment of ventricular arrhythmias. The current study was a prospective controlled evaluation of the effects of phenytoin on the disposition of disopyramide in normal volunteers. The objective was to determine if an interaction existed.
Type Text
Publisher University of Utah
Subject MESH Research Design; Anti-Arrhythmia Agents; Phenytoin; Disopyramide; Drug Interactions; Pharmacokinetics; Metabolic Clearance Rate; Half-Life; Biotransformation; Healthy Volunteers; Administration, Oral; Prospective Studies; Controlled Clinical Trials as Topic
Dissertation Institution University of Utah
Dissertation Name Doctor of Pharmacy
Language eng
Relation is Version of Digital Reproduction of The effect of phenytoin on the dispositon of disopyramide
Rights Management Copyright © Janice Rando 1984
Format application/pdf
Format Medium application/pdf
ARK ark:/87278/s6pk0x0r
Setname ir_etd
ID 195946
Reference URL https://collections.lib.utah.edu/ark:/87278/s6pk0x0r
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