Comparative analysis of plasma concentrations in once-a-day versus twice-a-day digoxin regimen in pediatric patients

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Title Comparative analysis of plasma concentrations in once-a-day versus twice-a-day digoxin regimen in pediatric patients
Publication Type dissertation
School or College College of Pharmacy
Department Pharmacotherapy
Author Klieman, Rachel L.
Date 1983-10
Description Digoxin is a valuable drug for a variety of cardiovascular disorders but is known to have a low margin of safety. While digoxin is used in pediatric patients for several cardiac conditions, there is some controversy over the most appropriate dose and dosage regimen. These are based on presumed differences in digoxin disposition and dose response relationships in infants and children as compared to adults. Two basic differences exist in the use of digoxin in children and adults. Children receive higher daily doses (based on body weight) and commonly receive the drug as two, rather than one, daily dose. There were two objectives to this study. The primary objective was to investigate if there was a significant difference in digoxin serum concentration obtained with a once-a-day and twice-a-day dosing. A secondary objective was to evluate the relationship between serum and salivary concentrations of digoxin.
Type Text
Publisher University of Utah
Subject MESH Research Design; Cardiotonic Agents; Digoxin; Pharmacokinetics; Drug Administration Schedule; Cross-Over Studies; Dose-Response Relationship, Drug; Serum; Saliva; Linear Models; Radioimmunoassay
Dissertation Institution University of Utah
Language eng
Relation is Version of Digital reproduction of Comparative analysis of plasma concentrations in once-a-day versus twice-a-day digoxin regimen in pediatric patients
Rights Management Copyright © Rachel L. Klieman 1983
Format application/pdf
Format Medium application/pdf
ARK ark:/87278/s6v700fh
Setname ir_etd
ID 195937
Reference URL https://collections.lib.utah.edu/ark:/87278/s6v700fh
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