The effect of rifampin on theophylline pharmacokinetic parameters (following intravenous aminophylline) in normal volunteers

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Title The effect of rifampin on theophylline pharmacokinetic parameters (following intravenous aminophylline) in normal volunteers
Publication Type dissertation
School or College College of Pharmacy
Department Pharmacotherapy
Author Boyce, Eric Glenn
Date 1984-08
Description Many drug interactions are discovered serendipitously. However, it is possible to predict the potential for ann interaction between two drugs based on the physical, chemical, pharmacokinetic, and pharmacological properties of those drugs. The effect of such an interaction on the patient is dependent on many factors, including the nature and magnitude of the interaction, and is therefore difficult to predict. A potential interaction would best be studied in a controlled experimental setting to limit the interference of variable and to protect the subjects. A potential interaction may exist between rifampin and theophylline. Rifampin has been shown to induce microsomal enzymes and to alter the clearance of many drugs. Theophylline is metabolized by microsomal enzymes and has demonstrated an increase in clearance following conditions that increase microsomal activity. To date, the interaction between these two drugs in humans has not been described, but a recent study demonstrated no interaction between these two dugs in rabbits. However, since the effect of rifampin on drug clearance has shown interspecies variation, an interaction between rifampin and theophylline may exist in humans.
Type Text
Publisher University of Utah
Subject MESH Research Design; Drug Interactions; Delayed-Action Preparations; Rifampin; Theophylline; Pharmacokinetics; Aminophylline; Administration, Intravenous; Administration, Oral; Healthy Volunteers; Metabolic Clearance Rate; Half-Life; Biotransformation; Drug-Related Side Effects and Adverse Reactions
Dissertation Institution University of Utah
Dissertation Name Doctor of Pharmacy
Language eng
Relation is Version of Digital reproduction of The effect of rifampin on theophylline pharmacokinetic parameters (following intravenous aminophylline) in normal volunteers
Rights Management Copyright © Eric Glenn Boyce 1984
Format application/pdf
Format Medium application/pdf
ARK ark:/87278/s6rf68vm
Setname ir_etd
ID 195930
Reference URL https://collections.lib.utah.edu/ark:/87278/s6rf68vm
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