Investigation of marine-derived fungi for bioactive natural products

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Title Investigation of marine-derived fungi for bioactive natural products
Publication Type dissertation
School or College College of Pharmacy
Department Medicinal Chemistry
Author Bugni, Timothy Scott
Contributor Bernan, Valerie; Mayne, Charles; Williamson, R. Thomas
Date 2003-08
Description The projects described in this dissertation are mainly focused on exploration of marine-derived fungi as a source of new pharmacologically active natural products. Fungi are prolific sources of medically useful secondary metabolites. Currently, fungi from marine habitats are relatively unexplored when compared to their terrestrial counterparts. The chemistry from marine-derived fungi is reviewed in Chapter 1. Chapter 2 describes fermentation studies performed on a series of marine-derived fungi. Although the fungi are not obligate marine fungal species, they are highly salt tolerant and some show increased production of antimicrobial secondary metabolites when cultured in the presence of artificial seawater. Overall, Chapter 2 summarizes the antimicrobial activities of nine fungal isolates that were grown using six different concentrations of artificial seawater. A class of antimicrobial famesylated epoxycyclohexenones, the yanuthones, is described in Chapter 3. The yanuthones were isolated fi^om an Aspergillus niger obtained from the tissue homogenate of an orange Aplidium sp. tunicate. The fermentation, the isolation, the structural elucidation, and the antimicrobial activities are discussed. Chapter 4 describes the first chemical investigation of a. Penicillium brocae. P. brocae is a rare species that had been formally described concurrently with the investigation described in Chapter 4. Fermentation of the P. brocae isolate resulted in the production of a novel class of polyketides, brocaenols A, B, and C. Additionally, the known metabolites, epicorazine A and B were isolated from P. brocae. The cytotoxic activity of epicorazine A is also briefly discussed. Chapter 5 describes two novel metabolites from a new Penicillium sp. obtained from the alga Dictyosphaeria versluyii. The isolation, structural elucidation, and antibacterial activity of two novel polyketides, dictyosphaeric acid A and B, is presented. Chapter 6 is the only chapter that does not involve marine-derived fungi. Rather, the antibacterial properties of the highly modified diterpenoid kalihinol class of sponge metabolites are presented. The chemistry of two Acanthella cavernosa sponges is reported and includes the description of two new kahhinol analogs, 10-formamido-kalihinol F and 15-formamido-kalihinol F. The studies presented in Chapter 6 show that some kalihinols inhibit bacterial folate biosynthesis.
Type Text
Publisher University of Utah
Subject Aspergillus niger; Aplidium; Pencillium brocae. Yanuthones
Subject MESH Pharmacology; Marine Biology; Fungi
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "Investigation of marine-derived fungi for bioactive natural products." Spencer S. Eccles Health Sciences Library. Print version of "Investigation of marine-derived fungi for bioactive natural products." available at J. Willard Marriott Library Special Collection. RS43.5 2003 .B84.
Rights Management © Timothy Scott Bugni.
Format application/pdf
Format Medium application/pdf
Format Extent 3,700,949 bytes
Identifier undthes,4892
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Master File Extent 3,700,985 bytes
ARK ark:/87278/s69k4d4f
Setname ir_etd
ID 191781
Reference URL https://collections.lib.utah.edu/ark:/87278/s69k4d4f
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