Topological analysis and visualization of mice temperature data for exploring biological events

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Title Topological analysis and visualization of mice temperature data for exploring biological events
Publication Type thesis
School or College School of Computing
Department Computing
Author Sharma, Avani
Date 2018
Description Recently, techniques from topological data analysis have been applied in various scientific domains ranging from brain imaging to sensor networks. In this thesis, we apply topological techniques in signal processing to study core body temperatures of mice. We focus on the exploration of biological events in a mouse model, in particular, pregnancies and jet lag. By combining signal processing techniques with cohomology parameterization, we create intuitive and informative visual profiles encoding periodic variations in mice temperature data. Using such visual profiles, we detect and separate successful pregnancies and pregnancy-like events. We further study the effect of jet lag on mice by clustering them into subcategories based on their topologically induced visual profiles. Jet lag has been shown to arise from critical biological factors such as travel, depression, liver cancer, and Alzheimer's disease. Our techniques have the potential to lead to new research directions in biology that investigate individual-level responses and variabilities in jet-lagged mice.
Type Text
Publisher University of Utah
Dissertation Name Master of Science
Language eng
Rights Management (c) Avani Sharma
Format application/pdf
Format Medium application/pdf
ARK ark:/87278/s6s2by08
Setname ir_etd
ID 1748480
Reference URL https://collections.lib.utah.edu/ark:/87278/s6s2by08
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