Synthetic design and biological activity of naamidine A, related natural products and analogues

This thesis describes the synthesis of several natural products, isolated from the marine sponges of the genus Leucetta, which have demonstrated an ability to influence a diverse range of biological processes, including the potential to inhibit important cancer signaling pathways. To understand this activity in more detail, the synthesis of naamidine A, related natural products and analogues was designed and implemented for the characterization of target binding in vitro and in vivo. In addition, the expansion of synthetic application used towards these natural products is described. The resulting methodology was used for the synthesis of 2-thio and 2-oxoimidazoles.