Clinical decision support for the whole genome sequence

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Title Clinical decision support for the whole genome sequence
Publication Type dissertation
School or College School of Medicine
Department Biomedical Informatics
Author Welch, Brandon Marshall
Date 2014-05
Description The widespread use of genomic information to improve clinical care has long been a goal of clinicians, researchers, and policy-makers. With the completion of the Human Genome Project over a decade ago, the feasibility of attaining this goal on a widespread basis is becoming a greater reality. In fact, new genome sequencing technologies are bringing the cost of obtaining a patient's genomic information within reach of the general population. While this is an exciting prospect to health care, many barriers still remain to effectively use genomic information in a clinically meaningful way. These barriers, if not overcome, will limit the ability of genomic information to provide a significant impact on health care. Nevertheless, clinical decision support (CDS), which entails the provision of patient-specific knowledge to clinicians at appropriate times to enhance health care, offers a feasible solution. As such, this body of work represents an effort to develop a functional CDS solution capable of leveraging whole genome sequence information on a widespread basis. Many considerations were made in the design of the CDS solution in order to overcome the complexities of genomic information while aligning with common health information technology approaches and standards. This work represents an important advancement in the capabilities of integrating actionable genomic information within the clinical workflow using health informatics approaches.
Type Text
Publisher University of Utah
Subject MESH Medical Informatics; Human Genome Project; Molecular Sequence Data; Genomics; Sequence Analysis, DNA; Computational Biology; Electronic Health Records; Delivery of Health Care; Computer Systems; Genome-Wide Association Study; Clinical Decision Support
Dissertation Institution University of Utah
Dissertation Name Doctor of Philosophy
Language eng
Relation is Version of Digital version of Clinical Decision Support for the Whole Genome Sequence
Rights Management Copyright © Brandon Marshall Welch 2014
Format application/pdf
Format Medium application/pdf
Format Extent 22,165,210 bytes
Source Original in Marriott Library Special Collections
ARK ark:/87278/s6m36402
Setname ir_etd
ID 196649
Reference URL https://collections.lib.utah.edu/ark:/87278/s6m36402
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