| Description |
Titanium dioxide nanotubes (TiO2-NTs) is such an attractive material because of photocatalysis, semiconductivity, biocompatibility, self-organization, and extremely large surface area. This thesis introduces several structural characteristics of TiO2-NTs synthesized by the electrochemical method. Although the research of biosensing platform using TiO2-NTs is not studied well, two types of biosensing platform systems will be discussed. At first, Tuberculosis (TB) detectable volatile biomarkers sensing platform using exhaled breath is studied. TB is easily cured at initial stage, thus the early diagnosis is a key point of fighting against TB. Breath analysis method is easier, faster, and cheaper while recent diagnosis methods require complicated conditions. Cobalt is functionalized on the nanotubes surface to detect the biomarker molecules in breath. The other application is the glutathione molecule detectable sensing platform. Glutathione protein is the scavenger of reactive oxygen species (ROS) which causes several diseases. The ratio of concentration of oxidized form and reduced form of glutathione molecules is served as a sign of the oxidative stress in body. Copper is loaded on the TiO2-NTs in order to hold glutathione molecules in liquid. From these experiments, the metal functionalized TiO2- NTs sensing platforms successfully detect their target biomarkers at vapor based and liquid based systems. |
