Assessment of long-term morphological and behavioral alterations and drug interventions post-hypoxia-ischemia

Update Item Information
Title Assessment of long-term morphological and behavioral alterations and drug interventions post-hypoxia-ischemia
Publication Type dissertation
School or College College of Pharmacy
Department Pharmacology & Toxicology
Author Biggs, Laura Ashley Filimon
Date 2009-08
Description Periventricular leukomalacia (PVL) occurs in pre-term infants and is often the result of a cerebral hypoxic-ischemic (HI) insult. PVL is characterized by white matter damage, a significantly increased risk of epilepsy, mental retardation, and/or cerebral palsy. A rat pup model of PVL has been used to characterize the susceptibility of the neonatal brain to hypoxia-ischemia-induced brain damage. The experiments conducted in this dissertation tested the hypothesis that HI results in sustained myelin basic protein (MBP) reductions, altered brain morphology, motor deficits and that levetiracetam, zonisamide, and/or lamotrigine may have potential efficacy as neuroprotective agents against HI induced brain damage and associated motor deficits. It remains unclear whether the damage observed at P7 persists into adulthood. Therefore, Specific Aim 1 will characterize Hl-induced effect on MBP and ventricular size at PI 1, P21 and P60. While, specific Aim 2 will characterize long-term motor deficits at P21 and P60. In addition, rats exposed to HI at P7 exhibit contralateral motor deficits at P21. Pharmacological intervention post-HI, using topiramate, is able to normalize both preoligodendrocyte cell loss and the motor deficit. Therefore, Specific aim 3 will assess the protective effects of topiramate, levetiracetam, zonisamide, and lamotrigine on HIinduced MBP lesions at P11 and motor deficits at P21.
Type Text
Publisher University of Utah
Subject MESH Leukomalacia, Periventricular; Hydrocephalus; Infant, Premature, Diseases; Hypoxia, Brain; Fetal Hypoxia; Encephalomalacia; Neuroprotective Agents; Drug Therapy; Zonisamide; Anticonvulsants
Dissertation Institution University of Utah
Dissertation Name Doctor of Philosopy
Language eng
Relation is Version of Digital version of Assessment of Long-Term Morphological and Behavioral Alterations and Drug Interventions Post-Hypoxia-Ischemia
Rights Management Copyright © Laura Ashley Filimon Biggs 2009
Format application/pdf
Format Medium application/pdf
Format Extent 3,678,464 bytes
Source Original in Marriott Library Special Collections
Conversion Specifications Original scanned on Fujitsu fi-5220G as 400 dpi to pdf using ABBYY FinerReader 10
ARK ark:/87278/s6wq0jdt
Setname ir_etd
ID 193532
Reference URL https://collections.lib.utah.edu/ark:/87278/s6wq0jdt
Back to Search Results