Experimental studies on bone marrow hypoplasia associated with drug administration

1. Attempts have been made to produce anaphylaxis in guinea pigs by the injections of mixtures of drugs and autologous blood. These attempts were unsuccessful. 2. Efforts were made to produce degenerative changes in the bone marrow and alterations in the blood by injection of homologous bone marrow in rabbits and guinea pigs. These efforts were unsuccessful. 3. The influence of bone marrow antisera upon the blood and bone marrow was observed in rabbits, guinea pigs, and swine. In rabbits a prompt and profound pancytopenia occurred after the injection of swine and guinea pig antiserum. With the continuous intravenous administration of bone marrow antiserum in rabbits, only a profound hemolytic anemia was observed, the leukocytes and platelets being normal in the blood. The bond marrow revealed erythroid hyperplasia. 4. The influence of chloramphenicol and its "diamine" congener upon the rate of growth and leukocyte count of weanling rats were observed. The development of anorexia, course and discolored hair, abdominal distension and diarrhea appeared to be due to the influence of the drug. Significant alterations in the leukocytes, did not appear to occur in relation to the administration of the drug.