Title | Idiopathic Intracranial Hypertension: Glymphedema of the Brain |
Creator | Patrick Nicholson; Alice Kedra; Eimad Shotar; Sophie Bonnin; Anne-Laure Boch; Natalia Shor; Frédéric Clarençon; Valérie Touitou; Stephanie Lenck |
Affiliation | Department of Neuroradiology (PN), Toronto Western Hospital, Toronto, Canada; Department of Neuroradiology (AK, ES, NS, FC, SL), Groupe Hospitalier Pitié Salpêtrière, Paris, France; Department of Ophthalmology (SB, VT), Groupe Hospitalier Pitié Salpêtrière, Paris, France; Department of Neurosurgery (ALB), Groupe Hospitalier Pitié Salpêtrière, Paris, France; GRC 31 E-HTIC (ES, SB, ALB, NS, VT, SL), Sorbonne University, Paris, France; Sorbonne University (ES, SB, NS, FC, VT, SL), Paris, France; and GRC BioFast (FC), Paris VI University, Paris, France |
Abstract | Background: During the last decade, our understanding of cerebrospinal fluid (CSF) physiology has dramatically improved, thanks to the discoveries of both the glymphatic system and lymphatic vessels lining the dura mater in human brains. |
Subject | Brain Edema; Cerebrospinal Fluid; Papilledema; Pseudotumor Cerebri |
OCR Text | Show State-of-the-Art Review Section Editors: Fiona Costello, MD, FRCP(C) Sashank Prasad, MD Idiopathic Intracranial Hypertension: Glymphedema of the Brain Patrick Nicholson, MD, Alice Kedra, MD, Eimad Shotar, MD, Sophie Bonnin, MD, Anne-Laure Boch, MD, Natalia Shor, MD, Frédéric Clarençon, MD, PhD, Valérie Touitou, MD, PhD, Stephanie Lenck, MD Downloaded from http://journals.lww.com/jneuro-ophthalmology by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0hCywCX1AWnYQp/IlQrHD3i3D0OdRyi7TvSFl4Cf3VC4/OAVpDDa8K2+Ya6H515kE= on 05/04/2022 Background: During the last decade, our understanding of cerebrospinal fluid (CSF) physiology has dramatically improved, thanks to the discoveries of both the glymphatic system and lymphatic vessels lining the dura mater in human brains. Evidence Acquisition: We detail the recent basic science findings in the field of CSF physiology and connect them with our current understanding of the pathophysiology of idiopathic intracranial hypertension (IIH). Results: Transverse sinus (TS) stenoses seem to play a major causative role in the symptoms of IIH, as a result of a decrease in the pressure gradient between the venous system and the subarachnoid space. However, the intracranial pressure can be highly variable among different patients, depending on the efficiency of the lymphatic system to resorb the CSF and on the severity of TS stenoses. It is likely that there is a subclinical form of IIH and that IIH without papilledema is probably underdiagnosed among patients with chronic migraines or isolated tinnitus. Conclusions: IIH can be summarized in the following pathological triad: restriction of the venous CSF outflow pathway—overflow of the lymphatic CSF outflow pathway— congestion of the glymphatic system. To better encompass all the stages of IIH, it is likely that the Dandy criteria need to be updated and that perhaps renaming IIH should be considered. Journal of Neuro-Ophthalmology 2021;41:93–97 doi: 10.1097/WNO.0000000000001000 © 2020 by North American Neuro-Ophthalmology Society BACKGROUND D uring the last decade, our understanding of cerebrospinal fluid (CSF) physiology has dramatically improved, thanks to the discoveries of both the glymphatic system and lymphatic vessels lining the dura mater in human brains. Although the characterization of CSF physiology is probably one of the most challenging projects in neuroscience, it is likely that these recent (and future) findings will have major clinical implications. The CSF circulation and the cerebrovascular system (including arteries, veins, and lymphatics) seem to be more intimately related than previously suspected. Given the ongoing work in this area, it is likely that our understanding of the overall image will probably evolve further in the near future. In particular, it is likely that we will gain a better understanding of the clinical and radiological features of idiopathic intracranial hypertension (IIH) in the broader context of these basic science findings (1,2). This, in turn, will probably lead to significant clinical and therapeutic advances. In this article, we detail the recent basic science findings in the field of CSF physiology and connect them with our current understanding of the pathophysiology of IIH. EVIDENCE ACQUISITION The Glymphatic System Department of Neuroradiology (PN), Toronto Western Hospital, Toronto, Canada; Department of Neuroradiology (AK, ES, NS, FC, SL), Groupe Hospitalier Pitié Salpêtrière, Paris, France; Department of Ophthalmology (SB, VT), Groupe Hospitalier Pitié Salpêtrière, Paris, France; Department of Neurosurgery (ALB), Groupe Hospitalier Pitié Salpêtrière, Paris, France; GRC 31 E-HTIC (ES, SB, ALB, NS, VT, SL), Sorbonne University, Paris, France; Sorbonne University (ES, SB, NS, FC, VT, SL), Paris, France; and GRC BioFast (FC), Paris VI University, Paris, France. The authors report no conflicts of interest. Address correspondence to Stéphanie Lenck, MD, Department of Neuroradiology, Service de Neuroradiologie, Bâtiment Babinski, Groupe Hospitalier Pitié Salpêtrière, 47-83 Boulevard de l’Hôpital, 75013 Paris, France; Email: stephanie.lenck@orange.fr Nicholson et al: J Neuro-Ophthalmol 2021; 41: 93-97 In 2012, Iliff et al (3) identified the glymphatic system as “a brain-wide pathway for fluid transport, which includes the para-arterial influx of subarachnoid CSF into the brain interstitium, followed by the clearance of interstitial fluid along large-caliber draining veins.” This process is preferentially activated during sleep (4) and is driven by a combination of arterial pulsatility, respiration, and pressure gradients (5,6). The exchange of water molecules between the 3 compartments of the brain (i.e., the blood, the CSF, and the brain parenchyma) is mediated by water-channel transporters called aquaporins (AQPs). 93 Copyright © North American Neuro-Ophthalmology Society. Unauthorized reproduction of this article is prohibited. State-of-the-Art Review The CSF is continuously produced by the choroid plexuses, which are expansions of the ependymal epithelium in the ventricles (7). The total constant volume is 150–160 mL in humans, and this volume is renewed approximately 4 times per day (8). The CSF production is mediated by osmotic and pressure gradients that drive the movement of water and ions from the blood to the ventricular lumen (4). The exchange of water molecules from the blood to the CSF is mediated by AQP-1, which is located in the apical membrane of the choroid plexus epithelial cells (9). From the ventricles, the CSF then exits through the foramina of Magendie and Monro to reach the subarachnoid space (4). Alternatively, the CSF may exit the ventricles through transependymal spread to reach the perivascular spaces of the brain. This transependymal spread pathway is especially apparent during cases of obstructive hydrocephalous. From the subarachnoid spaces, the CSF then enters the periarterial spaces, travelling from the cortex toward the deep white matter along the courses of the pial and perforator arteries (4). Along with other metabolites, the CSF is then filtered and driven from the periarterial space to the brain parenchyma (4). The transport of water from the CSF to the brain is mediated by another water transporter, AQP-4 (3). This water channel is expressed in astrocytic endfeet that ensheathe the brain vasculature (3). This continuous movement of the CSF from the periarterial space into the brain parenchyma then drives the convective bulk parenchymal fluid flow toward perivenous spaces surrounding the large cortical veins (3). After this, the method of resorption of the CSF from the perivenous spaces is still unclear. Two CSF outflow pathways have been described in humans: the venous outflow pathway and the lymphatic outflow pathway. Cerebrospinal Fluid Outflow Although the venous CSF outflow pathway has historically been considered as the only way of resorption of the CSF, the recent discovery of the dural lymphatics in humans (as distinct from the brain parenchymal glymphatic system outlined above) has been another major paradigm shift (10). To better describe the CSF outflow pathways, we first need to clearly distinguish 2 physiological roles of the CSF: a mechanical role (which plays a role in the regulation of the intracranial pressure [ICP]) and a metabolic one (which plays a role in the clearance of brain metabolites). The Venous Cerebrospinal Fluid Outflow Pathway It was historically believed that the venous resorption of the CSF occurs across the arachnoid villi and granulations. These anatomical structures are traditionally described as focal areas of protrusion of the subarachnoid space across the dura matter into the lumen of the dural sinuses. These “avascular granulations” also play a mechanical role of regulation of the ICP because the flow of the CSF across the granulation is dependent on the pressure gradient between 94 the subarachnoid space and the venous blood of the dural sinus. In the light of the recent scientific findings concerning the glymphatic system, it seems that another type of granulations—the so-called “vascular granulation”—has probably been wrongly neglected over time. Previous pathological (11,12) and radiological studies (12,13), support that some arachnoid granulations may enter the dura mater to reach the lumen of the venous sinuses in close association with a major cortical vein. These “vascular granulations” could represent an anatomical and physiological connection between the perivenous space (draining the interstitial fluid [ISF] from the glymphatic system) and the venous blood of the dural sinus (12). Vascular granulations may therefore be involved in the excretion of the brain metabolites as 1 final exit pathway of the glymphatic system. The intrinsic molecular mechanisms of this filtration are, however, still unknown. The Lymphatic Cerebrospinal Fluid Outflow Pathway It was long believed that the central nervous system did not have a lymphatic drainage system. Ironically, an Italian anatomist called Paola Mascagni described meningealrelated lymphatic vessels in a landmark anatomical text in 1787, but her findings were discounted by the scientific community for more than 200 years (14). In 2015, the presence of functional lymphatic vessels lining the dural sinuses was eventually demonstrated in murine brains (15,16). Two years later, Absinta et al went on to image these dural/meningeal lymphatics in both primates and humans (17). They also seem to be involved in the clearance of the CSF (or ISF) from the glymphatic system (15,18), and also in the regulation of the ICP (through a direct reabsorption of the CSF from the subarachnoid space) (16). Another work by Hoon Ahn et al, showed that CSF drains preferentially through a basal outflow pathway, with CSF tracers draining through skull base meningeal lymphatics to the deep cervical lymph node system. Anatomically, the lymphatic system of the brain could therefore be described as a drainage network extending from the dural sinuses to both eyes, tracking above the olfactory bulb, following the dural arteries and veins into the dura matter (15,16). The dural lymphatics finally join the skull base, discharging the CSF into the sheaths of the cranial nerves. The CSF is eventually excreted into the deep cervical lymph nodes and the systemic lymphatic circulation (19). RESULTS In the light of these scientific findings, the radiological signs of IIH can be summarized in the following pathological triad (Fig. 1) (1): 1. Congestion of the glymphatic system, 2. Overflow of the lymphatic CSF outflow pathway, and 3. Restriction of the venous CSF outflow pathway Nicholson et al: J Neuro-Ophthalmol 2021; 41: 93-97 Copyright © North American Neuro-Ophthalmology Society. Unauthorized reproduction of this article is prohibited. State-of-the-Art Review FIG. 1. The cascade of idiopathic intracranial hypertension. IIHWOP, idiopathic intracranial hypertension without papilledema; IIH, idiopathic intracranial hypertension; ICP, intracranial pressure. Idiopathic Intracranial Hypertension: Congestion of the Glymphatic System Several radiological studies indicate that IIH is associated with an increase in the CSF in the perivascular spaces of the brain and in the subarachnoid space, suggesting a congestion of the glymphatic system. Because the skull represents a fixed volume, the excess of CSF in the glymphatic system results in increased ICP. The first radiological observations of IIH were based on computed tomography (CT) and showed a reduction of the ventricular size, suggesting that IIH was due to cerebral swelling (20). This interstitial edema was confirmed later with MRI diffusion techniques and with 3D-volumetric MRI sequences (21). Alperin et al showed a significant increase in extraventricular CSF and ISF volumes in patients with IIH, when compared with a matched cohort of patients without IIH. Idiopathic Intracranial Hypertension: Overflow of the Lymphatic Cerebrospinal Fluid Outflow Pathway Imaging evidence of the excess CSF along the sheaths of cranial nerves is one of the cardinal signs of IIH (Fig. 2). Most typically, this is found along the optic nerve sheaths; however, the sheaths of other cranial nerves can also be enlarged. This may be a consequence of the accumulation of CSF along the sheaths of the cranial nerves. This excess of CSF seems to be related to the engorgement of the lymphatic CSF outflow pathway (22,23). For example, erosion of the cribriform plate (which may result in the idiopathic CSF leak) may be the consequence of the chronic overflow of CSF around the olfactory bulbs (24). Other cardinal imaging signs of IIH are also likely related to an excess of CSF along the relevant nerve sheaths. These imaging signs include widening of the foramen ovale and Meckel cave dilatation (CSF excess in the trigeminal nerve sheaths), enlargement of the third cranial nerve sheaths in the cavernous sinus (25,26), and enlargement of the Dorello canal Nicholson et al: J Neuro-Ophthalmol 2021; 41: 93-97 (indicating excess CSF in along the sheaths of CN VI). Finally, meningoceles of the temporal bone mostly located at the petrous apex or Meckel cave near the continuation of the nerve sheaths of the acoustic and facial nerves also point to an excess of CSF along these nerves. These can also lead to CSF leaks (27). Restriction of the Venous Cerebrospinal Fluid Outflow Pathway More than 90% of patients with IIH have transverse sinus (TS) stenoses, which are usually located bilaterally at the junction between the vein of Labbé and the TS (28). Those stenoses can result in increased cerebral venous pressure, leading in turn to a less efficient venous CSF outflow pathway as a result of equalization of the pressure gradient between the subarachnoid space and the venous blood of the dural sinuses. Although TS stenoses are probably the main precipitating factor in the occurrence of clinical symptoms in IIH—and the resolution of symptoms after venous stenting gives support to this hypothesis—the cause of these stenoses remains unclear. However, it is likely that a molecular impairment of CSF filtration at the venodural junction may be responsible for the formation of TS stenoses. We presume that the metabolic and hormonal factors associated with IIH (obesity, hormones, drugs, etc..) may be involved in this molecular trigger. Two types of venous sinus stenoses have been described in IIH: intrinsic and extrinsic (29). An intrinsic stenosis can be defined radiologically as a short-segment stenosis secondary to the presence of a subarachnoid granulation inside the sinus (30). Conversely, an extrinsic stenosis can be defined as a long-segment sinus stenosis without an endoluminal abnormality. Patients with intrinsic stenoses are often older than patients with extrinsic stenoses (29). In patients with intrinsic stenoses, the efficiency of the venous blood–CSF barrier can be impaired as outlined above. Paradoxically, the initial development of an arachnoid granulation may initially slightly delay the manifestation of IIH by increasing the exchange area between the 95 Copyright © North American Neuro-Ophthalmology Society. Unauthorized reproduction of this article is prohibited. State-of-the-Art Review FIG. 2. Radiological signs of idiopathic intracranial hypertension. A and B. T2-weighted MRI in coronal view showing the excess CSF along the sheaths of the optic nerves (A, horizontal arrowheads) and of the IIIrd cranial nerves (B, horizontal arrowhead), a petrous apex meningocele (B, oblique arrow), and the CSF leak across the cribriform plate (A, vertical arrowheads). C. CT in bone window showing the erosion of the cribriform plate (arrow). D. MR venography showing the bilateral transverse sinus stenoses (arrows). CSF and the venous system. The lymphatic outflow pathway may also initially compensate for the decreased efficiency of the venous CSF pathway. However, because it enlarges, the arachnoid granulation can eventually cause a mechanical obstruction in the venous sinus, which will then lead to increase pressure in the dural sinuses and, thus, to IIH symptoms as a result in impairment of the CSF venous outflow pathway. Extrinsic stenoses on the other hand affect younger patients than intrinsic stenoses. Two mechanisms may be involved in their formation. The first one is a direct compression of the TS by the congested brain and CSF, suggesting that intracranial hypertension is the cause of LS stenoses. This theory is supported by the disappearance of such extrinsic stenoses after removal of the CSF (31) and by their propensity to reform adjacent to the stented zone after stenting (32). De Simone et al (33) have hypothesized that the dural sinuses in IIH are hypercollapsible, to try to explain the mechanism of formation of extrinsic stenoses. CONCLUSIONS TS stenoses seem to play a major causative role in the symptoms of IIH. The suppression of the pressure gradient 96 between the venous system and the subarachnoid space can in turn lead to further inefficiency of the already impaired venous outflow pathway. Thus, the lymphatic outflow pathway becomes the only CSF outflow pathway of the brain, and the overflow of the CSF along the sheaths of the cranial nerves results in the classical clinical and radiological signs of IIH. The ICP may be highly variable amongst different patients, depending on the efficiency of the lymphatic system to resorb the CSF and on the severity of TS stenoses. This may explain why the radiological signs of IIH are frequently found in patients with chronic headache or isolated pulsatile tinnitus without papilledema or raised ICP. It is likely that there is a subclinical form of IIH in these patients, that is, in patients with a degree of CSF outflow impairment but in whom the signs and symptoms do not yet meet the criteria for IIH. It is therefore likely that IIH without papilledema (IIWOP), (i.e., with normal or near-normal ICP) is probably under diagnosed among patients with chronic migraines or isolated tinnitus (34). We suggest including the radiological signs in the next revision of the diagnostic criteria of IIH while putting a less value on the ICP value. This may be helpful to try and better capture the benign stages of this radio-clinical syndrome. Papilledema and raised ICP could Nicholson et al: J Neuro-Ophthalmol 2021; 41: 93-97 Copyright © North American Neuro-Ophthalmology Society. Unauthorized reproduction of this article is prohibited. State-of-the-Art Review probably therefore be considered as the most severe stage of the disease, whereas headache and pulsatile tinnitus with normal ICP (and without papilledema) could be considered as benign stages of IIH. 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Date | 2021-03 |
Language | eng |
Format | application/pdf |
Type | Text |
Publication Type | Journal Article |
Source | Journal of Neuro-Ophthalmology, March 2021, Volume 41, Issue 1 |
Collection | Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
Publisher | Lippincott, Williams & Wilkins |
Holding Institution | Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management | © North American Neuro-Ophthalmology Society |
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Setname | ehsl_novel_jno |
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Reference URL | https://collections.lib.utah.edu/ark:/87278/s65ee6e2 |