The Epidemiology of reproductive factors associated with breast cancer and their genetic interactions.

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Title The Epidemiology of reproductive factors associated with breast cancer and their genetic interactions.
Publication Type dissertation
School or College School of Medicine
Department Biomedical Informatics
Author Hunt, Steven Charles.
Contributor Skolnick, Mark
Date 1980-06
Description With the use of data from the Utah State Cancer Registry and Utah genealogical data, an epidemiological study of breast cancer patients and their matched controls showed that a late age at the birth of the first child was most strongly associated with incidence of breast cancer. The age at last delivery (ALD) was also associated with breast cancer, with a strong interaction between it and age at first delivery (AFD). The association of AFD with breast cancer incidence was strongest for women with an ALD before 35 years of age and born before 1900, even after adjustment for parity, while the AFD association was strong regardless of ALD for those women born after 1900. Decreased parity was not significantly associated with breast cancer. The genetic effects on AFD were evaluated by restricting the cancer patients to be analyzed to those that were related. This related group was chosen from the relationships that showed an excess number of related pairs compared to the expected number as determined by sets of matched controls. The association of AFD was stronger in this related sample than in the reference sample of unrelated women. The AFD association was also examined in a single large pedigree in which a dominant breast cancer gene is indicated. The women with breast cancer had a first delivery after 26 years of age 6.8 times more often than the unaffected women in the pedigree. There was a suggestion that AFD affected the development of breast cancer in this pedigree and had an additive effect to the presumed genetic mechanism. Finally, it was shown that the risk of incurring a second breast cancer was large compared to other cancers and that the second breast cancer occurred in the opposite breast more often than in the previously affected breast.
Type Text
Publisher University of Utah
Subject Biostatistics; Genetic-Epidemiology
Subject MESH Breast Neoplasms; Epidemiology
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "The Epidemiology of reproductive factors associated with breast cancer and their genetic interactions." Spencer S. Eccles Health Sciences Library. Print version of "The Epidemiology of reproductive factors associated with breast cancer and their genetic interactions." available at J. Willard Marriott Library Special Collection. RC 39.5 1980 H85.
Rights Management © Steven Charles Hunt.
Format application/pdf
Format Medium application/pdf
Identifier us-etd2,226
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Funding/Fellowship Public Health Service (PHS) grant CA16573-04 from the National Cancer Institute (NCI) and by PHS contract NO1-CP43382, through the Field Studies and Statistics Program, from the Division of Cancer Cause and Prevention, NCI.
ARK ark:/87278/s6cz3nn3
Setname ir_etd
ID 192523
Reference URL https://collections.lib.utah.edu/ark:/87278/s6cz3nn3
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