Alteration of murine mammary tumor metastasis and growth by cytomegalovirus infection

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Title Alteration of murine mammary tumor metastasis and growth by cytomegalovirus infection
Publication Type thesis
School or College School of Medicine
Department Pathology
Author Olsen, Gregg Arden
Contributor Weinhouse, Sidney.
Date 1980-06
Description Host resistance to the development of metastatic lesions is complex and involves both lymphocyte and macrophage functions. Studies in both humans and animals have suggested that cytomegalovirus infection may alter these components of the defense mechanism of the host. In the present study, an experimental model was developed to determine whether cytomegalovirus infection would affect host resistance to the establishment of metastatic tumor nodules in the lungs of C3H mice after intravenous inoculation of a single-cell suspension of mammary tumor cells. The number of tumor nodules in the lungs, the lungs-heart/body weight ratio, and the mean day of death were determined in control animals inoculated intravenously with 10^ mammary tumor cells and compared with groups of animals also receiving a sublethal intraperitoneal inoculum of murine cytomegalovirus (MCMV) (10^ plaque-forming units) either 3 days before, on the day of, or 10 or 13 days after tumor cell inoculation. The results suggest a biphasic effect of virus infection of tumor development in the lung. A preexisting or concurrent MCMV infection suppressed tumor growth and prolonged life, while a MCMV infection later in tumorigenesis enhanced tumor growth and shortened survival. These data suggest that MCMV modulates host resistance to the development of metastatic tumor nodules and that this experimental model may be utilized to investigate further the relationship betv/een virus-induced alterations of host defense mechanisms and tumor growth.
Type Text
Publisher University of Utah
Subject Cellular, Viral, and Molecular Biology
Subject MESH Cytomegalovirus; Neoplasm Metastasis
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "Alteration of murine mammary tumor metastasis and growth by cytomegalovirus infection." Spencer S. Eccles Health Sciences Library. Print version of "Alteration of murine mammary tumor metastasis and growth by cytomegalovirus infection." available at J. Willard Marriott Library Special Collection. QR 6.5 1980 O48.
Rights Management © Gregg Arden Olsen.
Format application/pdf
Format Medium application/pdf
Format Extent 991,824 bytes
Identifier undthes,4941
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Funding/Fellowship United States Public Health Service Grant AI 10217, National Cancer Institute grant CA 14165, and an award from the Upjohn Compant, Kalamazoo, Michigan.
Master File Extent 991,861 bytes
ARK ark:/87278/s67m09q1
Setname ir_etd
ID 191023
Reference URL https://collections.lib.utah.edu/ark:/87278/s67m09q1
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