Sedentary time and stress urinary incontinence in postpartum women: A comparison of isotemporal substitution and compositional data analysis techniques

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Title Sedentary time and stress urinary incontinence in postpartum women: A comparison of isotemporal substitution and compositional data analysis techniques
Publication Type project
School or College School of Medicine
Department Family & Preventive Medicine
Author Canning, Sarah
Date 2022
Description Vaginal childbirth is one of the most salient risk factors for future pelvic floor disorders, including stress urinary incontinence. As such, it is desirable to find modifiable factors during the postpartum period that may influence a woman's likelihood of developing these pelvic floor disorders. One factor that has been proposed to impact this probability is the amount of sedentary time a woman participates in during the postpartum period. Because a woman's sedentary time is constrained by the number of minutes she is awake, as well as the number of minutes she spends performing light physical activity and moderate-to-vigorous physical activity, statistical techniques that account for these constraints are required. Two such techniques are isotemporal substitution, which involves swapping a set amount of one activity for another activity while keeping the total constant, and compositional data analysis, which transforms the components of a whole from the constrained simplex space to the unconstrained real space. Both techniques were used within a modified Poisson regression model to estimate the prevalence of stress urinary incontinence at one year postpartum based on sedentary time at six months postpartum for first-time mothers. After adjusting for a number of confounders based on a DAG, a statistically significant relationship was not found between sedentary time and stress urinary incontinence using either isotemporal substitution (p=0.6815) or compositional data analysis (p=0.7315). This is likely related to the variables' relationship with BMI at different timepoints, as well as the healing process of the pelvic floor after birth. Although results from isotemporal substitution were easier to interpret, compositional data analysis better accounts for potential asymmetric results when substituting activities for sedentary time and vice versa. An improved method for this type of analysis involves components of both isotemporal substitution and compositional data analysis.
Type Text
Publisher University of Utah
Subject Isotemporal substitution; Compositional data analysis; Physical activity; Sedentary time; Stress urinary incontinence; Postpartum
Dissertation Name Masters of Statistics, Biostatistics
Language eng
Rights Management (c) Sarah Canning
Rights License MStat Biostatistics Project Report
Format application/pdf
Format Medium application/pdf
ARK ark:/87278/s62p5hna
Setname ir_etd
ID 1766688
Reference URL https://collections.lib.utah.edu/ark:/87278/s62p5hna
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