MEK Inhibitor Treatment Promotes Retinal Ganglion Cell Preservation without Preventing Retrobulbar Demyelination in Neurofibromatosis Mice

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Identifier 20190319_nanos_sciplatform3_04-abstract
Title MEK Inhibitor Treatment Promotes Retinal Ganglion Cell Preservation without Preventing Retrobulbar Demyelination in Neurofibromatosis Mice
Creator Steven Stasheff; Francisco Nadal-Nicolas; Wei Li; Miriam Bornhorst; Yuan Zhu
Affiliation (SS) Neuroscience & Gilbert NF Inst, Children's National Health Sys; National Eye Institute, Washington, District of Columbia; (FN) (WL) (YZ) Retinal Neurophysiology Section, National Eye Institute, Bethesda, Maryland; (MB) (YZ) Gilbert Neurofibromatosis Institute, Children's National Health System, Washington, District of Columbia
Subject Pediatric Neuro-Ophthalmology; Neuro-Ophth & Systyemic Disease (eg. MS, MG, Thyroid); Genetic; Disease; Chemotherapy and Radiation Injury; Higher Visual Functions
Description To better understand the disparity frequently seen between optic pathway glioma (OPG) characteristics and visual loss among young children with neurofibromatosis type 1 (NF1), we extend our previous findings of anatomic, physiologic, and behavioral abnormalities in an established animal model. We now report differential effects of treatment targeting the MAPK/ERK cellular pathway: 1) preserving retinal ganglion cell (RGC) number, and yet 2) failing to ameliorate demyelination of the retrobulbar optic nerve.
Date 2019-03
Language eng
Format application/pdf
Type Text
Source 2019 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS 2019: Scientific Platform III
Collection Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2019. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6wh74p1
Setname ehsl_novel_nam
ID 1422863
Reference URL https://collections.lib.utah.edu/ark:/87278/s6wh74p1
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