The effect of metyrapone on the elimination kinetics and metabolic fate of acetaminophen in man

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Title The effect of metyrapone on the elimination kinetics and metabolic fate of acetaminophen in man
Publication Type dissertation
School or College College of Pharmacy
Department Pharmacotherapy
Author Pribble, John Patrick
Date 1985-12
Description Acetaminophen is a commonly used analgesic and antipyretic which when taken in recommended doses is both safe and effective. However, acetaminophen ingested in large doses such as encountered in suicide attempts, may result in massive, sometimes fatal, hepatic and renal necrosis. Acetaminphen-induced hepatotoxicity results from the metabolic conversion of acetaminophen to a quantitatively minor reactive metabolite by cytochrome P-450-mediated oxidation. Direct inhibition of this role of metabolism may be useful in the treatment of acetaminophen overdose, possibly as an adjunct to N-acetylcysteine. To date, few clinical trials have been conducted to support the use of cytochrome P-450 inhibitors in this setting.
Type Text
Publisher University of Utah
Subject MESH Research Design; Metyrapone; Antimetabolites; Acetaminophen; Pharmacokinetics; Metabolic Clearance Rate; Urine; Saliva; Cytochrome P-450 Enzyme System; Drug Overdose; Antidotes; Hepatotoxicity; Plasma Concentration
Dissertation Institution University of Utah
Dissertation Name Doctor of Pharmacy
Language eng
Relation is Version of Digital reproduction of The effect of metyrapone on the elimination kinetics and metabolic fate of acetaminophen in man
Rights Management Copyright © John Patrick Pribble 1985
Format application/pdf
Format Medium application/pdf
ARK ark:/87278/s68g91jt
Setname ir_etd
ID 195926
Reference URL https://collections.lib.utah.edu/ark:/87278/s68g91jt
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