Mitochondrial Disease and Glaucoma

There are several mitochondrial optic neuropathies (MON). There are probably many glaucomas. So perhaps it is not surprising that there exist overlaps in these two conditions. More importantly, however, the pathogenic mechanisms recently elucidated in MON may provide insights and opportunities in the management of at least some glaucomas. Furthermore, there is a growing body of evidence that mitochondrial disease may affect tissues of the eye other than retinal ganglion cells (eg. trabecular meshwork and the optic nerve) and may even directly alter some of the dynamics that determine intraocular pressure1. The purpose of this talk and manuscript is to delve into the relationship between mitochondria and glaucoma.