The effect of cimetidine on serum concentrations of piroxicam

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Title The effect of cimetidine on serum concentrations of piroxicam
Publication Type dissertation
School or College College of Pharmacy
Department Pharmacotherapy
Author Mailhot, Claude
Date 1985-05
Description Drug interactions are a major factor in the etiology of adverse drug reactions. Because patients often take more than one medication, the possibility of a patient experiencing an adverse drug interaction is of concern. Numerous drug interactions caused by cimetidine, a potent H2 receptor antagonist, have been documented in humans. Cimetidine has been shown to decrease the elimination of a variety of drugs including, antiprrine, aminopyrine, chlordiazepoxide, diazepam, warfarin, theophylline, quinidine, carbamazepine, and phenytoin. All of the above mentioned drugs are eliminated after metabolism by mixed function oxidases in the liver, suggesting that cimetidine inhibits the action of the cytochrome P-450 oxidative enzymes. Assuming that the hydroxylation of piroxicam is cytochrome P-450 mediated, the addition of cimetidine to the therapeutic regimen of a patient on piroxicam could result in a decrease in piroxicam elimination and prolongation of its effect. Prolongation of the antiprostaglandin effect is of clinical concern because it may increase the hazard of renal dysfunction in patients at risk. The purpose of this study was to determine if serum concentrations of piroxicam following a single oral dose are altered by previous and concurrent administration of cimetidine.
Type Text
Publisher University of Utah
Subject MESH Research Design; Cimetidine; Piroxicam; Serum; Pharmacokinetics; Drug-Related Side Effects and Adverse Reactions; Cytochrome P-450 Enzyme System; Metabolic Clearance Rate; Renal Plasma Flow; Drug Interactions; Arthritis, Rheumatoid
Dissertation Institution University of Utah
Dissertation Name Doctor of Pharmacy
Language eng
Relation is Version of Digital reproduction of The effect of cimetidine on serum concentrations of piroxicam
Rights Management Copyright © Mailhot, Claude 1985
Format application/pdf
Format Medium application/pdf
ARK ark:/87278/s6w38b51
Setname ir_etd
ID 195960
Reference URL https://collections.lib.utah.edu/ark:/87278/s6w38b51
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