Comparison of 1.5 Tesla and 3.0 Tesla Magnetic Resonance Imaging in the Evaluation of Acute Demyelinating Optic Neuritis

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Title Comparison of 1.5 Tesla and 3.0 Tesla Magnetic Resonance Imaging in the Evaluation of Acute Demyelinating Optic Neuritis
Creator Minjun Hur; Ajay A. Madhavan; David O. Hodge; Laurence J. Eckel; Sean J. Pittock; Eoin P. Flanagan; M. Tariq Bhatti; John J. Chen
Affiliation Departments of Ophthalmology (MH, MTB, JJC) and Radiology (AAM, LJE), Mayo Clinic, Rochester, Minnesota; Division of Biostatistics (DOH), Mayo Clinic and Mayo Foundation, Rochester, Minnesota; and Department of Neurology (SJP, EPF, MTB, JJC), Mayo Clinic, Rochester, Minnesota
Abstract Background: Optic neuritis (ON) is the most common optic neuropathy in young adults. MRI is reported to have a high sensitivity for ON. Higher signal strengths of MRI may enhance resolution and lead to better detection of ON. We sought to compare the sensitivity of 3.0 Tesla (T) MRI to that of 1.5 T MRI in detecting acute demyelinating ON. Methods: A retrospective chart review was performed on patients with a clinical diagnosis of optic neuritis at Mayo Clinic Health System from January 2010 to April 2020. Among 1,850 patients identified, 126 patients met the eligibility criteria. Exclusion criteria comprised questionable or alternative diagnosis, diagnosis of ON before the study period, eye examinations performed elsewhere, or absence of fat-saturated head and orbits MRIs performed locally within 30 days of symptom onset. Gadolinium contrast enhancement, T2 hyperintensity, and the radiologic diagnosis of ON were recorded by a neuro-radiologist who was masked to the clinical history and the magnet strength of the MRI. Results: Fifty-three patients (42.1%) had 3.0 T MRI, and 73 patients (57.9%) had 1.5 T MRI. Overall, 88.9% (112/126) of patients were determined to have a positive MRI for ON. The radiographic sensitivity for ON was higher in the 3.0 T group compared with the 1.5 T group (98.1% vs 82.2%, respectively [ P = 0.004]). The frequency of gadolinium enhancement was found to be greater in the 3 T group compared with the 1.5 T group (98.1% vs 76.7%, respectively [ P < 0.001]). T2 hyperintensity was also more often seen in the 3.0 T group compared with the 1.5 T group (88.7% vs 68.5%, respectively [ P = 0.01]). Conclusions: 3.0 T MRI is more sensitive than 1.5 T MRI in detecting ON. This finding suggests that 3.0 T MRI is a preferred imaging modality for the confirmation of ON.
Subject Contrast Media; Gadolinium; Magnetic Resonance Imaging; Optic Neuritis; Retrospective Studies; Young Adult
OCR Text Show
Date 2022-09
Date Digital 2022-09
References 1. Voss E, Raab P, Trebst C, Stangel M. Clinical approach to optic neuritis: pitfalls, red flags and differential diagnosis. Ther Adv Neurol Disord. 2011;4:123-134.2. Gala F. Magnetic resonance imaging of optic nerve. Indian J Radiol Imaging. 2015;25:421-438. 3.Berg S, Kaschka I, Utz KS, Huhn K, Lämmer A, Lämmer R, Waschbisch A, Kloska S, Lee DH, Doerfler A, Linker RA. Baseline magnetic resonance imaging of the optic nerve provides limited predictive information on short-term recovery after acute optic neuritis. PLoS One. 2015;10:e0113961. 4. Bursztyn LLCD, De Lott LB, Petrou M, Cornblath WT. Sensitivity of orbital magnetic resonance imaging in acute demyelinating optic neuritis. Can J Ophthalmol. 2019;54:242-246. 5. Hickman SJ, Toosy AT, Miszkiel KA, Jones SJ, Altmann DR, MacManus DG, Plant GT, Thompson AJ, Miller DH. Visual recovery following acute optic neuritis-a clinical, electrophysiological and magnetic resonance imaging study. J Neurol. 2004;251:996-1005.
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, September 2022, Volume 42, Issue 3
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s69yp0ve
Setname ehsl_novel_jno
ID 2344183
Reference URL https://collections.lib.utah.edu/ark:/87278/s69yp0ve
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