Detection of Thyroid Abnormalities in Aquaporin-4 Antibody-Seropositive Optic Neuritis Patients

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Title Detection of Thyroid Abnormalities in Aquaporin-4 Antibody-Seropositive Optic Neuritis Patients
Creator Shuo Zhao; Huanfen Zhou; Xudong Peng; Shaoying Tan; Zihao Liu; Tingjun Chen; Quangang Xu; Shihui Wei
Affiliation Department of Ophthalmology (SZ), Beijing Hospital, Beijing, China; Department of Ophthalmology (HZ), The First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing, China; Department of Ophthalmology (ST, TC, QX, SW), The Chinese People's Liberation Army General Hospital, Beijing, China; Department of Health Care (XP), The Chinese People's Liberation Army General Staff Department Guard Bureau, Beijing, China; and Department of Ophthalmology (ZL), The Chinese Dongzhimen Hospital, Beijing, China
Abstract Objective: This study retrospectively analyzed the frequency of anti-thyroid antibodies (ATAs) and thyroid disease in patients with optic neuritis (ON). Methods: Tests of serum thyroglobulin (TG) and thyroid peroxidase (TPO) antibodies and thyroid function were performed in 97 ON patients. Blood also was drawn to test for AQP4-Ab using cell-based and enzyme-linked immunosorbent assays. Comparisons of the frequencies of ATAs, thyroid diseases and thyroid function were performed based on AQP4-Ab status. Results: Seropositive AQP4-Ab was found in 47/97 (48.5%) patients. ATA was considered positive in 34/97 (35.1%) patients. The prevalence of ATA was two times higher (P = 0.019) in the AQP4-Ab+ group compared to the AQP4-Ab- group. AQP4-Ab+ ON patients exhibited lower FT3 (P = 0.006) and FT4 (P = 0.025) levels and a higher prevalence of definite Hashimoto thyroiditis (HT) (P = 0.005). Among AQP4-Ab+ patients, those with HT had a worse visual outcome than non-HT patients. Conclusion: A high prevalence of ATAs and HT was found in AQP4-Ab+ ON patients, and AQP4-Ab+ patients with HT exhibited worse visual outcomes than non-HT patients.
Subject Adult; Aquaporin 4; Autoantibodies; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Optic Neuritis; Optic Neuritis; Optic Neuritis; Retrospective Studies; Thyroid Diseases
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Date 2017-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6q85k0q
Setname ehsl_novel_jno
ID 1353373
Reference URL https://collections.lib.utah.edu/ark:/87278/s6q85k0q
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