Treatment Response in Pediatric Patients With Pseudotumor Cerebri Syndrome

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Title Treatment Response in Pediatric Patients With Pseudotumor Cerebri Syndrome
Creator Eliel Tovia, MD; Shimon Reif, MD; Asaf Oren, MD; Alexis Mitelpunkt, MD; Aviva Fattal-Valevski, MD, MHA
Affiliation Pediatrics Department (ET, SR, AO) and Pediatric Neurology Unit (AM, AFV), Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Abstract Pseudotumor cerebri syndrome (PTCS) is a disorder defined by increased intracranial pressure in the absence of an intracranial space-occupying lesion. This retrospective study aimed to examine the outcomes in children with PTCS. Data was collected retrospectively from the charts of consecutive pediatric patients treated for PTCS at our hospital between 2000 and 2007 (60 patients; 36 females, 24 males). Forty-six patients (76.6%) responded well to acetazolamide therapy, with full resolution of symptoms, including papilledema (average treatment duration 1 year; range: 1 month-5 years). Of the 14 patients with no response to treatment, 9 (23.4%) required surgical intervention. Nonresponders tended to be younger at presentation (8.7 vs 11.5 years, P = 0.04). Twelve patients (26%) experienced relapse after acetazolamide was discontinued. The group that experienced relapse was significantly younger than the nonrelapsers (8.9 vs 12.1 years, P < 0.05). Younger age at presentation with PTCS was found to be a risk factor for treatment failure or relapse.
Subject Acetazolamide; Adolescent; Brain; Child; Child, Preschool; Diuretics; Drug Therapy, Combination; Female; Follow-Up Studies; Forecasting; Fructose; Furosemide; Glucocorticoids; Humans; Intracranial Pressure; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Pseudotumor Cerebri; Retrospective Studies; Spinal Puncture; Topiramate; Treatment Outcome
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Date 2017-12
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, December 2017, Volume 37, Issue 4
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s61k3pkq
Setname ehsl_novel_jno
ID 1400785
Reference URL https://collections.lib.utah.edu/ark:/87278/s61k3pkq
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