Identifier |
walsh_2024_s1_c5 |
Title |
Go Back to the House, MD |
Creator |
Marc Bouffard |
Affiliation |
(MB) Harvard Medical School |
Subject |
Botulism; Pupil; Ptosis; Diplopia; Autonomic Failure |
Description |
A 72-year-old man presented to the emergency department with dysarthria and a left facial droop. He was in his usual state of health prior to the day of presentation. His social worker described him as being at his baseline on the morning of presentation, only to find him immobile with a facial droop, dysarthria, and incontinence several hours later. His medical history included hypertension, hyperlipidemia, and aspiration pneumonia complicated by delirium. Medications included lisinopril, furosemide, aspirin, carvedilol, and atorvastatin. No allergies were known. His family history was unclear. He was previously undomiciled but more recently lodged in state-sponsored housing with other previously homeless individuals. His substance use history was unknown. The initial examination, conducted by a neurology resident in the emergency department, revealed a disheveled patient with insect bites on his appendages. He answered simple questions but seemed inattentive (e.g., calling out for water). The cranial nerve examination revealed complete, non-supranuclear ophthalmoparesis OU but was otherwise normal, including reactive pupils and visual fields which were full to finger counting. His face appeared symmetric. The motor examination was limited but revealed symmetric anti-gravity movement throughout. Light touch was intact throughout. Reflexes, coordination, and gait were not assessed. Aspiration pneumonia was identified and he was started on antibiotics and IV thiamine. After admission, systolic blood pressures increased to the 200s. The neurology attending examination revealed preserved ability to follow commands despite an inability to open eyes. Blink to threat was absent. Pupils reacted from 3.5-3 on hospital day 2 but were fixed by hospital day 3 at 4.5mm. Eyes were conjugate with complete ophthalmoplegia and absent vestibulo-ocular reflexes in all directions. Corneal reflexes were very weak and cough was absent. No movement was noted proximally, though he could weakly squeeze hands and wiggle toes symmetrically. Tone was low. Reflexes were absent. |
History |
CSF examination revealed 0 WBC, 1 RBC, protein 78, and a glucose of 96. MRI brain revealed FLAIR hyperintensities in the brainstem, basal ganglia, and subcortical white matter without abnormal post-contrast enhancement or diffusion restriction. The history was revisited with a painstaking "yes/no" interview involving hand squeezing. The patient denied an antecedent diarrheal illness, recreational drug use, or alcohol use. He endorsed consumption of bulging, dented, and expired canned goods in the setting of food insecurity. Social work investigated his home and found multiple damaged canned goods. Botulinum antitoxin was requested from the CDC and administered in parallel with IVIg for possible Miller-Fisher. EMG subsequently revealed "severe motor process without signs of denervation." GQ1b was < 1:100. The ganglioside panel, porphyrins, Mayo autoimmune encephalopathy panel from serum and CSF, Ma/Ta, and C.botulinum culture from stool returned negative. A serum assay for Clostridium botulinum toxin (Type A) returned positive from the CDC, establishing a diagnosis of foodborne botulism. On hospital day 19, a meeting was held with his estranged family who reported that he would not want to be intubated for any reason for any duration of time. He was terminally extubated and died. This patient's presentation was classic for botulism, involving multiple cranial nerve palsies (featuring mydriasis and ophthalmoplegia), descending paralysis, and parasympathetic failure (hypertension, thirst) 1. Botulism is a rare cause of multiple cranial neuropathies2. Wernicke's and an evolving brainstem infarct (near locked-in) were considered given the patient's acute decline, but after MRI brain was unrevealing and his status worsened despite IV thiamine, Miller-Fisher/Bickerstaff, botulism, Lambert-Eaton, and brainstem encephalitides were promptly considered. Revisiting the history, despite the inherent difficulty in doing so, clarified the diagnosis. 1. Penas SC, et al. Ophthalmic manifestations in 18 patients with botulism. J Neuro-Ophth 2005;25:262-267. 2. Keane JR. Multiple cranial nerve palsies. Arch Neurol 2005;62(11):1714-1717. |
Disease/Diagnosis |
Foodborne botulism |
Date |
2024-03 |
References |
None provided. |
Language |
eng |
Format |
video/mp4 |
Type |
Image/MovingImage |
Source |
2024 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
2024 Frank B. Walsh Sessions: Session I |
Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
Publisher |
North American Neuro-Ophthalmology Society |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management |
Copyright 2024. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s665wysb |
Setname |
ehsl_novel_fbw |
ID |
2592818 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s665wysb |