MS and the Immune System

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Identifier 20230315_nanos_neuroimmunology1_01
Title MS and the Immune System
Creator Jennifer Graves, MD, PhD, MAS
Affiliation UCSD, San Diego, CA
Subject Multiple Sclerosis; Autoimmunity; Genetics; Aging; Sex Differences
Description Multiple sclerosis is a multifactorial autoimmune disease of the central nervous system with three primary targets of the brain, spinal cord and optic nerves. Based on monozygotic twin studies, the heritability of MS is 25%. Over the last decade of advances in genome wide association studies, 48% of that heritability has now been explained by > 200 MS risk alleles, the majority of which are associated with immune genes. The closest genetic cousins of MS are other autoimmune diseases and not neurodegenerative diseases.
Date 2023-03
References 1. International MS Genetics Consortium. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility Science 2019. Vol 365; No. 6460. Sept 27. 2. Fitzgerald, KC, et al. Early complement genes are associated with visual system degeneration in multiple sclerosis. Brain 2019. Vol 142. Pages 2722-2736. Sept 1. 3. Attfield, KE, Jensen, LT, kaufman, M, Friese, MA, Fugger, L. The Immunology of Multiple Sclerosis. Nature Reviews Immunology 2022. May 4th. 4. Graves, JS, Krysko, KM, Hua, LH, Absinta, M, Franklin, JM, Segal, BM. Ageing and Multiple Sclerosis. Lancet Neurology. Oct 7 2022. Online First. 5. Krysko KM, Henry RG, Cree BAC, et al. Telomere length is associated with disability progression in multiple sclerosis. Ann Neurol 2019; 86: 671-82.
Language eng
Format application/pdf
Format Creation Microsoft PowerPoint
Type Text
Source 2023 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS Annual Meeting 2023: Neuroimmunology: https://novel.utah.edu/collection/NAM/toc/
Collection Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6fgjtpb
Setname ehsl_novel_nam
ID 2386611
Reference URL https://collections.lib.utah.edu/ark:/87278/s6fgjtpb
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