Parinaud's Syndrome

Two examples of patients with Parinaud's syndrome, a dorsal midbrain syndrome. Discussion of hallmarks of this syndrome, including convergence retraction nystagmus, vertical gaze palsies, light-near dissociation, and Collier's Sign. Discussion of age-dependent disorders associated with this syndrome, including multiple sclerosis and encephalitis for younger patients, and vascular disease in older patients. First patient is shown to have full lateral eye movements, normal rapid refixation saccades, and impaired saccades in upward gaze, as well as a lack of strong reaction to light. Second patient is shown to have impaired upward pursuit, but normal horizontal pursuit. With vestibular ocular stimulation, vertical gaze is closer to normal.