Publication Type |
thesis |
School or College |
School of Medicine |
Department |
Pathology |
Author |
Erickson, Lance Karl |
Title |
Posterior homeotic transformation of the cervical-thoracic border is a marker of maldevelopment in humans |
Date |
2012-08 |
Description |
This study was initiated after observing a high incidence of cervical ribs in stillborn fetuses referred for autopsy at our institution. The study establishes the prevalence of cervical ribs in this referral population and describes related associations. Radiologic data were reviewed from 389 stillborn and 171 liveborn autopsies performed at Primary Children's Medical Center from 2006 to 2011. Cervical ribs were identified in 49.1% of stillborn fetuses and 22.8% of liveborn infants at the time of autopsy. There was a statistically significant high association of cervical ribs in patients with aneuploidy. Karyotypes were available on 186 of the stillborn cases (47%). Of the patients with chromosome abnormality, 24 of 32 (75%) had cervical ribs. Our findings support the hypothesis that cervical ribs, a posterior homeotic transformation of the cervical-thoracic border, represent disadvantageous development during early stages of blastogenesis. This same region and patterning of the anterior to posterior skeletal axis has been conserved throughout evolution in almost all mammals. |
Type |
Text |
Publisher |
University of Utah |
Subject MESH |
Genes, Homeobox; Transcription Factors; Gene Expression Regulation, Developmental; Body Patterning; Cervical Rib; Thoracic Vertebrae; Gastrulation; Congenital Abnormalities |
Dissertation Institution |
University of Utah |
Dissertation Name |
Master of Science |
Language |
eng |
Relation is Version of |
Digital reproduction of Posterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of the Maldevelopment in Humans. Spencer S. Eccles Health Sciences Library. Print version available at J. Willard Marriott Library Special Collections. |
Rights Management |
Copyright © Lance Karl Erickson 2012 |
Format Medium |
application/pdf |
Format Extent |
1,479,277 bytes |
Source |
Original in Marriott Library Special Collections, RG41.5 2012.E75 |
ARK |
ark:/87278/s6w414hq |
Setname |
ir_etd |
ID |
196345 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6w414hq |