Study of the antigenicity and antiseptic properties of chloroform and bromoform substituted products of otho-mata- and parachlorobenzaldenydeparachlorobenzaldenyde

Update Item Information
Title Study of the antigenicity and antiseptic properties of chloroform and bromoform substituted products of otho-mata- and parachlorobenzaldenydeparachlorobenzaldenyde
Publication Type thesis
School or College School of Medicine
Department Pathology
Author Logan, Lucille McDonald
Date 1940
Description 1. The bromo-substituted compounds of ortho-, meta- and para- chlorophenylcarbinol appear to be more active agents for producing sensitization in guinea pigs than are the respective chloro-substituted compounds. 2. The position of the substituted group in this series of compounds appears to have a definite bearing on the production of hypersensitiveness. In general the para-substituted compounds are seemingly the most active in production of cutaneous sensitivity and anaphylactic symptoms. 3. The presence of anaphylactic antibodies was demonstrated in guinea pigs injected with three compounds which were the most irritating; namely, tribromo-methyl-m-chlorophenylcarbinol, trichloromethyl-p-chloro-phenylcarbinol and tribromomethyl-p-chlorophenylcarbinol. One of these compounds, trichloromethyl-p-chloropharylcarbinol, failed to show cutaneous sensitivity. 4. The compounds in oil are bacteridal for E. typhi and bacteriostatic foar Staphylococous aureus. 5. As antiseptics, demonstrated by the agar cup plate method, the bromo-substituted compounds were more effective than the chloro-substituted compounds, the paraoriented compounds being effective in the highest dilutions.
Type Text
Publisher University of Utah
Subject Agglutination; Chemical Specificity
Subject MESH Chlorophenols; Antigens; Skin; Guinea Pigs
Dissertation Institution University of Utah
Dissertation Name MA
Language eng
Relation is Version of Digital reproduction of "A Study of the antigenicity and antiseptic properties of chloroform and bromoform substituted products of otho-mata- and parachlorobenzaldenyde." Spencer S. Eccles Health Sciences Library. Print version of "A Study of the antigenicity and antiseptic properties of chloroform and bromoform substituted products of otho-mata- and parachlorobenzaldenyde." available at J. Willard Marriott Library Special Collection. QR6.5 1940 .L65.
Rights Management © Lucille McDonald Logan.
Format application/pdf
Format Medium application/pdf
Format Extent 7,038,124 bytes
Identifier undthes,4882
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Master File Extent 7,038,167 bytes
ARK ark:/87278/s6nz89d6
Setname ir_etd
ID 190981
Reference URL https://collections.lib.utah.edu/ark:/87278/s6nz89d6
Back to Search Results