Ectopic Melanopsin for Visual Restoration: Compressed Cell-Specific Promotors - a Translatable Delivery Mechanism
Creator
Michael Gilhooley; Moritz Lindner; Steven Hughes; Mark Hankins
Affiliation
(MG) University of Oxford & Moorfields Eye Hospital, Oxford, United Kingdom of Great Britain and Northern Ireland; (ML) Institute of Physiology and Pathophysiology, Philipps University, Marburg, Germany; (SH) (MH) University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland
Subject
Genetic Disease; Retina; Pupil; Miscellaneous
Description
Exogenous expression of Melanopsin renders neural cells sensitive to light. It is a prime candidate for clinical optogenetic approaches to visual restoration,especially when applied to theneuroretinal tissue surviving ininherited retinal degenerations (IRDs). We previously demonstrated that targeting expression of melanopsin to retinal ON-bipolar cells, using a transgenic ‘Cre.lox' model, led to the restoration of more naturalistic response characteristics in an IRD. However, an alternativeclinically translatable mechanism of targeting melanopsin is required to allow therapeutic use.
Date
2021-02
Language
eng
Format
video/mp4
Type
Image/MovingImage
Source
2021 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of
NANOS Annual Meeting 2021: Scientific Platform Session II