A 50-year old female with with bi-frontal headache and blurred vision OU. Previous history significant for hyperlipidemia and gastroesophageal reflux disease.
Pathology
Epithelioid cells with pleomorphic nucleoli and a high mitotic rate demonstrated.
Disease/Diagnosis
Leptomeningeal primary melanomatosis
Clinical
Binocular horizontal diplopia
Presenting Symptom
Headache; Blurred vision
Neuroimaging
CT; MRI
Treatment
Antineoplastic agents
Date
2006
References
1. Bar H, Schlote W. Malignant melanoma in the CNS, subtyping and immunocytochemistry. Clin Neuropathol. 1997;16:337-45. 2. Kesari S, Batchelor T. Leptomeningeal metastases. Neurologic Clinics. 2003;21: 25-66. 3. Lopez-Castilla J. Primary leptomeningeal melanoma in a child. Pediatr Neurol. 2001;24:390-2. 4. Pirini M, et al. Primary diffuse meningeal melanomatosis: radiologic-pathologic correlation. AJNR Am J Neuroradiol. 2003;24:115-8. 5. Thorton C, et al. Primary malignant melanoma of the meninges. Clin Neuropathol. 1988; 7:244-8.
Language
eng
Format
video/mp4
Type
Image/MovingImage
Source
32nd Annual North American Neuro-Ophthalmology Society Meeting, 2006 Frank B. Walsh Session
