Influence of cannabidiol and delta 9-tetrahydrocannabinol on cobalt epilepsy in rats

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Title Influence of cannabidiol and delta 9-tetrahydrocannabinol on cobalt epilepsy in rats
Publication Type dissertation
School or College College of Pharmacy
Department Pharmacology & Toxicology
Author Chiu, Pauline
Date 1978-08
Description The mechanisms of the anticonvulsant activity of cannabidiol (CBD) and the central excitation of delta9- -tetrahydrocannabinol (Delta9 -THC) were investigated electrophysiologically with conscious, unrestrained cobalt epileptic rats. The well-known antiepileptics, trimethadione, ethosuximide and phenytoln, were included as reference drugs. Direct measurements were made of spontaneously firing, epileptic potentials from a primary focus on the parietal cortex and convulsions were monitored visually. Ethosuximide and trimethadione decreased the frequency of focal potentials, but phenytoin and CBD exerted no such effect. Although CBD did not suppress the focal abnormality, it abolished jaw and limb clonus. Consequently, CBD may produce its anticonvulsant effect by depressing seizure spread in the CNS. In contrast, delta9-THC markedly increased the frequency of focal potentials, evoked generalized bursts of polyspikes and produced frank convulsions, 11-OH-delta9 -THC, the major metabolite of delta -THC displayed only one of the excitatory properties of the parent compound: production of bursts of poiyspikes. In contrast to delta-THC and its 11-OH-metabolite, CBD, even in very high doses, did not induce any excitatory effects or convulsions. The present study provides the first evidence that CBD exerts anticonvulsant activity against the motor manifestations of a focal epilepsy, and that the mechanism of the effect may involve a depression of seizure spread in the CNS.
Type Text
Publisher University of Utah
Subject Tetrahydrocannabinol
Subject MESH Anticonvulsants; Cannabinoids
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "The influence of cannabidiol and delta 9-tetrahydrocannabinol on cobalt epilepsy in rats." Spencer S. Eccles Health Sciences Library. Print version of "The influence of cannabidiol and delta 9-tetrahydrocannabinol on cobalt epilepsy in rats." available at J. Willard Marriott Library Special Collection. RM 31.5 1978 C45.
Rights Management © Pauline Chiu.
Format application/pdf
Format Medium application/pdf
Format Extent 980,728 bytes
Identifier undthes,4977
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Master File Extent 980,758 bytes
ARK ark:/87278/s6w37z2r
Setname ir_etd
ID 190483
Reference URL https://collections.lib.utah.edu/ark:/87278/s6w37z2r
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