Multidomain Cognitive Impairment in Children With Pseudotumor Cerebri Syndrome

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Title Multidomain Cognitive Impairment in Children With Pseudotumor Cerebri Syndrome
Creator M. Mahajnah; A. T. Suchi; H. Zahakah; R. Sharkia R; Shuhaiber SR; Srugo I; Genizi J.
Abstract Background: Although prompt and suitable treatment of pseudotumor cerebri syndrome (PTCS) leads to an excellent prognosis and can prevent optic nerve atrophy, adults show long-lasting neurocognitive deficits even with prompt treatment. The purpose of our study was to evaluate cognitive outcomes in pediatric patients with PTCS. Methods: We performed a prospective study on children diagnosed with PTCS and a healthy control group. Children with pre-existing neurological conditions or psychiatric drug use were excluded. Both groups underwent a neurocognitive evaluation, using the NeuroTrax computerized battery of tests. The PTCS group were tested 3 months after the initial diagnosis. Results: We evaluated 82 children (49 females [60%], 6.5-16 years old, mean age 13.3), including 26 diagnosed with idiopathic PTC and 56 controls. Global cognitive score (P < 0.001), verbal memory (P < 0.001), executive function (P < 0.001), attention (P< 0.003), and information processing speed (P < 0.004) were all significantly lower in the PTCS group. No differences were found between children currently being treated and those whose symptoms had resolved and treatment was stopped. Conclusions: Children with PTCS experience comprehensive cognitive decline that persists after the resolution of the symptoms and treatment.
Subject Cognitive Dysfunction; Prospective Studies; Pseudotumor Cerebri
OCR Text Show
Date 2022-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, March 2022, Volume 42, Issue 1
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6ez0ynq
Setname ehsl_novel_jno
ID 2197497
Reference URL https://collections.lib.utah.edu/ark:/87278/s6ez0ynq
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