Acetazolamide-Induced Nephrolithiasis in Idiopathic Intracranial Hypertension Patients

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Title Acetazolamide-Induced Nephrolithiasis in Idiopathic Intracranial Hypertension Patients
Creator Johnathan N. Au, MPH; Carin S. Waslo, MPH; Gerald McGwin Jr, PhD; Carrie Huisingh, MPH; Emanuel Tanne, MD
Affiliation Casey Eye Institute (JNA, CSW, ET), Oregon Health & Science University, Portland, Oregon; Chicago Medical School (JNA), Rosalind Franklin University of Medicine and Science, Chicago, Illinois; Department of Ophthalmology (CH, GM), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Intracranial Hypertension Research Foundation (ET), Vancouver, Washington
Abstract Mitochondrial encephalopathy, lactic acidosis, and stroke-like symptoms (MELAS) and MIDD (maternally-inherited diabetes mellitus and deafness) are caused by A3243G transfer RNA mutations that affect mitochondrial function. Hearing loss and early onset diabetes mellitus constitute the main MIDD phenotype. Regarding the ophthalmologic manifestations of MIDD, we hypothesized that decreased vestibulo-ocular reflex (VOR) gain in patients with MIDD may contribute to impaired dynamic visual acuity.; ; Neuro-ophthalmologic, neuroimaging, and neuro-otologic evaluations were performed in 2 nonrelated patients with MIDD who complained of oscillopsia with head movement. We obtained quantitative recording of the horizontal and the vertical VOR, using the video head impulse test device.; ; In the 2 patients, we detected visual, ocular motor, and vestibular abnormalities. Decreased VOR gain in the planes of all 3 semicircular canals and impaired dynamic visual acuity was demonstrated in both cases.; ; MIDD patients are primarily recognized by their advanced hearing loss or deafness, early onset diabetes mellitus, and lactic acidosis. Decreased vision in these patients relates primarily to peri-macular retinal atrophy. In addition, loss of vestibular function causes poor dynamic visual acuity. Both patients, in their late fifties, had evidence of progressive central and peripheral nervous system dysfunction.
Subject Deafness; Diabetes Mellitus, Type 2; Eye Movements; Female; Hearing Loss; Humans; Male; Middle Older people; Mitochondrial Diseases; Mutation; Ocular Motility Disorders; Pedigree; RNA; Vestibular Diseases; Visual Acuity
OCR Text Show
Date 2016-06
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, June 2016, Volume 36, Issue 2
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6pp315d
Setname ehsl_novel_jno
ID 1276486
Reference URL https://collections.lib.utah.edu/ark:/87278/s6pp315d
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