Lambert-Eaton Myasthenia Syndrome Initial Presentation Mimicking Myasthenia Gravis

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Title Lambert-Eaton Myasthenia Syndrome Initial Presentation Mimicking Myasthenia Gravis
Creator S. Y. Uhm; H. Nguyen; K. P. Kanakia; J. E. Carter
Affiliation Departments of Ophthalmology (HN, JEC), University of Texas Health Science Center at San Antonio, San Antonio, Texas; Departments of Neurology (KPK, JEC), University of Texas Health Science Center at San Antonio, San Antonio, Texas; the Joe R. and Teresa Lozano Long School of Medicine (SU), San Antonio, Texas
Abstract The neuromuscular junction disorders myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) both present with muscle weakness but usually have clinical features that distinguish the 2 disorders (1-3).
Subject Myasthenia Gravis; Lamber-Eaton Syndrome
OCR Text Show
Date 2023-06
Date Digital 2023-06
References 1. Nicolle MW. Myasthenia gravis and lambert-eaton myasthenic syndrome. Contin Lifelong Learn Neurol. 2016;22:1978-2005. 2. Schoser B, Eymard B, Datt J, Mantegazza R. Lambert-Eaton myasthenic syndrome (LEMS): a rare autoimmune presynaptic disorder often associated with cancer. J Neurol. 2017;264:1854-1863. 3. Oh SJ. Myasthenia gravis Lambert-Eaton overlap syndrome. Muscle Nerve. 2016;53:20-26. 4. Wirtz PW, Verschuuren JJ, Van Dijk JG, et al. Efficacy of 3,4-diaminopyridine and pyridostigmine in the treatment of lambert-eaton myasthenic syndrome: a randomized, double-blind, placebo-controlled, crossover study. Clin Pharmacol Ther. 2009;86:44-48. 5. Lindquist S, Stangel M. Update on treatment options for Lambert-Eaton myasthenic syndrome: focus on use of amifampridine. Neuropsychiatr Dis Treat. 2011;7:341-349. 6. Titulaer MJ, Lang B, Verschuuren JJGM. Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. Lancet Neurol. 2011;10:1098-1107. 7. Nair AG, Patil-Chhablani P, Venkatramani DV, Gandhi RA. Ocular myasthenia gravis: a review. Indian J Ophthalmol. 2014;62:985-991. 8. Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. Lyon, France: IARC Press; 2004. 9. Wirtz PW, Sotodeh M, Nijnuis M, et al. Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome. J Neurol Neurosurg Psychiatry. 2002;73:766-769. 10. Lipka AF, Titulaer MJ, Tannemaat MR, Verschuuren JJGM. Lowering the cutoff value for increment increases the sensitivity for the diagnosis of Lambert-Eaton myasthenic syndrome. Muscle Nerve. 2020;62:111-114. 11. Natarajan B, Saifudheen K, Gafoor VA, Jose J. Accuracy of the ice test in the diagnosis of myasthenic ptosis. Neurol India. 2016;64:1169-1172. 12. Chatzistefanou KI, Kouris T, Iliakis E, et al. The ice pack test in the differential diagnosis of myasthenic diplopia. Ophthalmology. 2009;116:2236-2243. 13. Katyal N, Govindarajan R. Pure ocular weakness as the initial manifestation of lambert-eaton myasthenic syndrome. Cureus. 2017;9:2-6. 14. Jia R, Chen J, Ge R, Zheng Q, Chen F, Zhao Z. Coexistence of myasthenia gravis and Lambert-Eaton myasthenic syndrome in a small cell lung cancer patient: a case report. Med. 2018;97. doi:10.1097/MD.0000000000010976. 15. Sanders DB. Lambert-Eaton myasthenic syndrome: diagnosis and treatment. In: Annals of the New York Academy of Sciences. 2003;998:500-508. 16. Toyoda Y, Nakayama T, Kusunoki Y, Iso H, Suzuki T. Sensitivity and specificity of lung cancer screening using chest low-dose computed tomography. Br J Cancer. 2008;98:1602-1607. 17. Li HR, Gao J, Jin C, Jiang JH, Ding JY. Comparison between CT and MRI in the diagnostic accuracy of thymic masses. J Cancer. 2019;10:3208-3213.
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, June 2023, Volume 43, Issue 2
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s687j38d
Setname ehsl_novel_jno
ID 2498921
Reference URL https://collections.lib.utah.edu/ark:/87278/s687j38d
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