Determination of total oxidant status by dietary assessment and association with blood and urine biomarkers

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Title Determination of total oxidant status by dietary assessment and association with blood and urine biomarkers
Publication Type thesis
School or College College of Health
Department Nutrition & Integrative Physiology
Author Artz, Tamara Lee
Date 2012-12
Description Oxidant status may influence conception after in vitro fertilization, maternal health during pregnancy, and fetal outcomes including birthweight. However, few reports exist of oxidant status in women of childbearing potential. Oxidant status may be influenced by the intake of antioxidant vitamins, minerals, and phytochemicals. The purpose of this study was to examine the intake of antioxidant vitamins and minerals, measure biomarkers of oxidative stress, and evaluate the association between them. We conducted a cross-sectional study of dietary and supplement intake and measurements for biomarkers of oxidative status (malondialdehyde (MDA), glutathione (GSH), and 8- isoprostane) in women of childbearing potential. Intake was measured using a food frequency questionnaire and an overall index of dietary quality was generated (the Healthy Eating Index-2005). Additionally, a new, integrated index of oxidant stress from dietary variables, the diet oxy-score, was calculated with intake for specific antioxidant vitamins and minerals. The total oxidant status from the biomarkers was created by integrating the measured values of MDA, GSH, GSH/GSSG ratio, and 8-isoprostane into one index. Oxidative status measured with biomarkers was correlated in a biologically plausible direction with the dietary index of oxidative status, the Healthy Eating Index- 2005, zinc, manganese, vitamin E, !-carotene, iron, and selenium. The observed correlations suggest that appropriate diet and supplementary zinc, manganese, vitamin E, B carotene, iron, and selenium intake may be an effective strategy for augmenting oxidantstatus in women of childbearing potential.
Type Text
Publisher University of Utah
Subject biomarkers, diet, dietary assessment, oxidant status, Oxidative stress
Dissertation Institution University of Utah
Dissertation Name Master of Science
Language eng
Rights Management Copyright © Tamara Lee Artz 2012
Format application/pdf
Format Medium application/pdf
Format Extent 2,140,606 bytes
ARK ark:/87278/s6cv4zjt
Setname ir_etd
ID 195618
Reference URL https://collections.lib.utah.edu/ark:/87278/s6cv4zjt
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