Development of animal models for evaluation of technetium-99m renal tubular function agents

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Title Development of animal models for evaluation of technetium-99m renal tubular function agents
Publication Type dissertation
School or College College of Pharmacy
Department Pharmaceutics & Pharmaceutical Chemistry
Author Eshima, Dennis
Date 1985-06
Description Diamide dimercaptide (N2S2) and triamide mercaptide (N3S) complexes of technetium-99m were shown to have potential use as a new class of renal tubular function agents. The biological evaluation of a number of these new Tc-99m chelating agents was performed in order to develop an optimal animal strategy for the screening of these agents as well as other potential complexes. Various animal models were studied to determine the potential correlation of the rate of renal clearance and the specificity for the renal transport system between the various animal species and humans. There was no single animal species which could routinely predict the performance of the complexes in humans. Therefore, the use of a select number of performance parameters, which were obtained from studies in the mouse, rat or dog were utilized to develop a set of criteria to predict the performance in humans. The use of these animal models minimized extrapolation errors, if limitation were placed on the amount of information which would be utilized from each of them. There were an number of complexes which appeared promising when evaluated in view of these species limitations. The evaluation of Tc-99m-mercaptoacetylglgcylglycylglycine (Tc-99m-MAG3) was found to perform will in all of the various animal models. Tc-99m-MAG3 was therefore utilized to develop an understanding for its pathway of elimination. The results from these studies show that Tc-99m-MAG3 is cleared from the body by the kidneys primarily by renal tubular secretion processes.
Type Text
Publisher University of Utah
Subject Technetium; Isotopes; Radiophamaceuticals; Physiology
Subject MESH Technetium; Radioisotopes; Kidney Function Tests; Organotechnetium Compounds
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "Development of animal models for evaluation of technetium-99m renal tubular function agents". Spencer S. Eccles Health Sciences Library. Print version of "Development of animal models for evaluation of technetium-99m renal tubular function agents". available at J. Willard Marriott Library Special Collection. RM 31.5 1985 E83.
Rights Management © Dennis Eshima.
Format application/pdf
Format Medium application/pdf
Format Extent 2,212,134 bytes
Identifier undthes,4511
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Master File Extent 2,212,211 bytes
ARK ark:/87278/s6q52rcj
Setname ir_etd
ID 190345
Reference URL https://collections.lib.utah.edu/ark:/87278/s6q52rcj
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