Immunity to histoplasmosis induced in mice by components of Histoplasma capsulatum

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Title Immunity to histoplasmosis induced in mice by components of Histoplasma capsulatum
Publication Type dissertation
School or College School of Medicine
Department Pathology
Author Anderson, Kenneth Leroy
Date 1968-08
Description Twenty-three strains of Histoplasma capsulatum were studied. The data indicated that each strain had individual characteristics with regard to: macroscopic appearance of colonies, measurement of spore sizes, relative number of spores, virulence as determined by intravenous LD50 in mice, immunization capacity of vaccines, and chemical composition of the vaccines prepared from four strains. Strains G10, G17M, 2645, and 3330 were used to study the immunogenicity of the fungus, A cell free extract prepared from the mycelial phase of strain G10 and a cell free extract prepared from the yeast phase of strain G17M produced similar protection in immunized mice, G10 and G17M vaccines also had similar chemical composition with high carbohydrate content and low protein content. Strains 3154 and G17M were found to be the most virulent by the method employed. The sporulation number, as determined by a rank rating system, showed that each strain produced various numbers of both types of spores, The results indicated that Sabouraud's medium with phosphate ion produced abundant and numerous spores. The macroscopic description of each strain on various media indicated that each strain varies in morphological characteristics depending on the nutrition available.
Type Text
Publisher University of Utah
Subject Immunology; Mycelial
Subject MESH Histoplasmosis; Yeasts; Mice
Dissertation Institution University of Utah
Language eng
Relation is Version of Digital reproduction of "Immunity to histoplasmosis induced in mice by components of Histoplasma capsulatum." Spencer S. Eccles Health Sciences Library. Print version of "Immunity to histoplasmosis induced in mice by components of Histoplasma capsulatum." available at J. Willard Marriott Library Special Collection. QR6.5 1968 .A53.
Rights Management © Kenneth Leroy Anderson.
Format application/pdf
Format Medium application/pdf
Format Extent 1,617,720 bytes
Identifier undthes,4809
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Funding/Fellowship Publich Healst Service Grant (AI-K6-14,924) from the National Institutes of Health.
Master File Extent 1,617,749 bytes
ARK ark:/87278/s6z60qx2
Setname ir_etd
ID 191598
Reference URL https://collections.lib.utah.edu/ark:/87278/s6z60qx2
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