Walsh & Hoyt: Endocrinology

In 1929, Cushing and Eisenhardt observed that meningiomas, which occur much more frequently in women than in men, may become symptomatic during pregnancy. It has subsequently become clear that meningiomas frequently enlarge or become symptomatic during pregnancy and during the luteal phase of the menstrual cycle. There is no evidence, however, that meningiomas present more often during pregnancy. In addition, there is an increased incidence of meningioma among women with breast carcinoma the only significant association between a nervous system neoplasm and a primary malignancy elsewhere in the body. These findings suggest that at least some meningiomas are under hormonal influence.